Dendritic Cell (DC) and Tumor-Specific Cytotoxic T Cell (CTL) Generation Protocol from Healthy Volunteers and Patients with Malignant Brain Tumors
The purpose of this project is to perform a series of studies aimed at developing a dendritic cell-based vaccine for patients with malignant brain tumors. In preparation for a Phase I clinical trial, we wish to validate our ability: (1) To generate and phenotypically and functionally characterize large numbers of DCs generated from patients with malignant brain tumors; (2) To optimize the efficiency of transfection of DCs with tumor RNA, and; (3) To generate cytotoxic T lymphocyte reactivity to the tumor-specific antigens with these DCs.
KeywordsBrain Tumors, Glioblastoma multiforme, Metastatic brain tumor, Glioma
Principal InvestigatorDuane A Mitchell, M.D.
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