Biobehavioral mechanisms underlying symptoms and healing outcomes in older individuals with CVLU


The purpose of this study is to elucidate the complex biobehavioral mechanisms responsible for symptoms and healing outcomes for older adults with venous leg ulcers (VLUs) for the development of targeted therapies that address both the patient-oriented outcomes and healing outcomes in this growing group of affected individuals. Individuals living with chronic VLU (CVLU) have a high symptom burden of both wound-related symptoms and symptoms of pain, depression, anxiety, fatigue and cognitive dysfunction, collectively labeled as “psychoneurologic symptoms (PNS).” The specific aims of the proposed study are to: (1) Characterize the strength of the associations at baseline among patient-host factors, systemic inflammation, and wound microenvironment with wound area and symptoms (PNS and wound-related); and, (2) Test associations and models over time for: (a) Patient-host factors and systemic inflammation with wound microenvironment; (b) Patient-host factors and wound microenvironment with systemic inflammation; (c) Patient-host factors, systemic inflammation, and wound microenvironment with wound healing; (d)  Patient-host factors, systemic inflammation, and wound microenvironment with symptoms (PNS and wound-related) and (e) Patient-host factors, systemic inflammation, wound microenvironment and wound healing with symptoms (PNS and wound-related).  To achieve the specific aims, we will longitudinally examine 200 older adults (age >60) who are receiving state of the art, standardized wound treatment biweekly across eight weeks’ time.





Monetary compensation


Can be done from home



Psychoneurologic symptoms, PNS, chronic venous leg ulcers, CVLUs, Biobehavioral Mechanisms

Principal Investigator

Debra Lyon, Executive Aso Dean & Kirbo Endowed Chair

Sponsoring Group

Department of Neurology



Contact Information


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