Paul Okunieff, M.D.

Paul Okunieff, M.D. - Research & Publications

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Publications

Radiation-induced tumor immunity in patients with non-small cell lung cancer
Thoracic Cancer
2019

Oligometastatic breast cancer treated with hypofractionated stereotactic radiotherapy: Some patients survive longer than a decade
Radiotherapy and Oncology
2019

Hypofractionated Stereotactic Radiotherapy for Non-breast or Prostate Cancer Oligometastases: A Tail of Survival Beyond 10 Years
Frontiers in Oncology
2019

Enhancing Career Paths for Tomorrow's Radiation Oncologists
International Journal of Radiation Oncology Biology Physics
2019

An in-silico quality assurance study of contouring target volumes in thoracic tumors within a cooperative group setting
Clinical And Translational Radiation Oncology
2019

The Importance of Imaging in Radiation Oncology for National Clinical Trials Network Protocols
International Journal of Radiation Oncology Biology Physics
2018

Stereotactic Ablative Body Radiotherapy for Primary Non-Small-Cell Lung Cancer: Achieving Local Control with a Lower Biologically Effective Dose.
Cancer Investigation
2018

Single-Fraction Radiosurgery Using Conservative Doses for Brain Metastases: Durable Responses in Select Primaries With Limited Toxicity
Neurosurgery
2018

Report From the Swog Radiation Oncology Committee: Research Objectives Workshop 2017
Clinical Cancer Research
2018

DcR3, a new biomarker for sepsis, correlates with infection severity and procalcitonin
Oncotarget
2018

Classification for long-term survival in oligometastatic patients treated with ablative radiotherapy: A multi-institutional pooled analysis.
PLOS One
2018

A novel approach for fast detection of sepsis with Gram-negative bacterial infection.
Microbial Biotechnology
2018

Triptolide Mitigates Radiation-Induced Pneumonitis Via Inhibition of Alveolar Macrophages and Related Inflammatory Molecules
Oncotarget
2017

Tlr9 Mediated Regulatory B10 Cell Amplification Following Sub-Total Body Irradiation: Implications in Attenuating Eae

2017

Glucose Enhances Rotavirus Enterotoxin-Induced Intestinal Chloride Secretion
Pflugers Archiv-European Journal of Physiology
2017

Ensuring Sample Quality for Blood Biomarker Studies in Clinical Trials: a Multicenter International Study for Plasma and Serum Sample Preparation
Translational Lung Cancer Research
2017

Comparison of three different methods for the detection of circulating tumor cells in mice with lung metastasis
Oncology Reports
2017

Amino Acid Hydration Decreases Radiation-Induced Nausea in Mice: A Pica Model
Advances in Experimental Medicine and Biology
2017

Triptolide Mitigates Radiation-Induced Pulmonary Fibrosis Via Inhibition of Axis of Alveolar Macrophages-Noxes-Ros-Myofibroblasts

2016

Synthesis and anticancer potential of novel xanthone derivatives with 3,6-subsituted changes

2016

An Amino Acid-Based Oral Rehydration Solution (Aa-Ors) Enhanced Intestinal Epithelial Proliferation in Mice Exposed to Radiation
Scientific Reports
2016

Triptolide Mitigates Radiation-Induced Pulmonary Fibrosis
Radiation Research
2015

Triptolide Mitigates Radiation-Induced Pulmonary Fibrosis
Radiation Research
2015

Stereotactic Body Radiotherapy for Lung Metastases from Colorectal Cancer: Prognostic Factors for Disease Control and Survival
American Journal of Clinical Oncology
2015

Radiotherapy for Brain Metastases From Renal Cell Carcinoma in the Targeted Therapy Era: The University of Rochester Experience
American Journal of Clinical Oncology
2015

PicoGreen assay of circular DNA for radiation biodosimetry
Radiation Research
2015

Performance of the HPV-16 L1 methylation assay and HPV E6/E7 mRNA test for the detection of squamous intraepithelial lesions in cervical cytological samples

2015

Development and validation of a HPLC-MS/MS method for the determination of phytolaccagenin in rat plasma and application to a pharmacokinetic study
Journal of Pharmaceutical and Biomedical Analysis
2015

Development and Validation of a Hplc-Ms/Ms Method for the Determination of Phytolaccagenin in Rat Plasma and Application To a Pharmacokinetic Study
Journal of Pharmaceutical and Biomedical Analysis
2015

Brain metastasis from melanoma: the prognostic value of varying sites of extracranial disease
Journal of Neurooncology
2015

Brain Metastasis From Melanoma: the Prognostic Value of Varying Sites of Extracranial Disease
Journal of Neuro-Oncology
2015

Sbrt for Oligometastatic Non-Small Cell Lung Cancer
International Journal Of Radiation Oncology Biology Physics
2014

Radiation-Induced Viral Activation in Hpv-Associated Squamous Cell Carcinoma of the Oropharynx: a Prospective Analysis of Viral Expression in Saliva During Radiation Therapy
International Journal Of Radiation Oncology Biology Physics
2014

Ptip Down-Regulation Enhances Radiation-Induced Tumor Cell Suppression In-Vitro and On Cam
International Journal Of Radiation Oncology Biology Physics
2014

Proton therapy for skull base chordomas: an outcome study from the university of Florida proton therapy institute
Journal of Neurological Surgery Part B-Skull Base
2014

Proton Therapy for Skull Base Chordomas: An Outcome Study From the University of Florida Proton Therapy Institute
Journal of Neurological Surgery Part B-Skull Base
2014

Mitochondrial genetic abnormalities after radiation exposure
Advances in Experimental Medicine and Biology
2014

Mitochondrial Genetic Abnormalities After Radiation Exposure

2014

Mitochondrial DNA and functional investigations into the radiosensitivity of four mouse strains
International Journal of Cell Biology
2014

Mitochondrial DNA and functional investigations into the radiosensitivity of four mouse strains
International Journal of Cell Biology
2014

Glucose stimulates calcium-activated chloride secretion in small intestinal cells
American Journal of Physiology-Cell Physiology
2014

Glucose Stimulates Calcium-Activated Chloride Secretion in Small Intestinal Cells
American Journal of Physiology-Cell Physiology
2014

Design and synthesis of isosteviol triazole conjugates for cancer therapy
Molecules
2014

Design and Synthesis of Isosteviol Triazole Conjugates for Cancer Therapy

2014

Consequences of anorectal cancer atlas implementation in the cooperative group setting: Radiobiologic analysis of a prospective randomize in silico target delineation study
Radiotherapy and Oncology
2014

Consequences of Anorectal Cancer Atlas Implementation in the Cooperative Group Setting: Radiobiologic Analysis of a Prospective Randomized in Silico Target Delineation Study
Radiotherapy and Oncology
2014

An amino acid mixture mitigates radiation-induced gastrointestinal toxicity

2014

A new flavonoid regulates angiogenesis and reactive oxygen species production
Advances in Experimental Medicine and Biology
2014

A basic fibroblast growth factor analog for protection and mitigation against acute radiation syndromes

2014

A New Flavonoid Regulates Angiogenesis and Reactive Oxygen Species Production

2014

A Mobile Positron Activation Detection System for Post-Proton Therapy Tumor Blood Flow Measurements
International Journal Of Radiation Oncology Biology Physics
2014

Tumor oxygen measurements and personalized medicine
Advances in Experimental Medicine and Biology
2013

Tumor Oxygen Measurements and Personalized Medicine

2013

The role of mitochondrial proteomic analysis in radiological accidents and terrorism
Advances in Experimental Medicine and Biology
2013

The murine common deletion: mitochondrial DNA 3,860-bp deletion after irradiation
Radiation Research
2013

The Role of Mitochondrial Proteomic Analysis in Radiological Accidents and Terrorism

2013

Stem cell senescence: a double-edged sword?
Journal of the National Cancer Institute
2013

Stem Cell Senescence: a Double-Edged Sword?

2013

Reduction of Decoy Receptor 3 Enhances Trail-Mediated Apoptosis in Pancreatic Cancer
PLOS One
2013

Reduction of Decoy Receptor 3 Enhances TRAIL-Mediated Apoptosis in Pancreatic Cancer
PLOS One
2013

Radiation affects the responsiveness of bone marrow to G-CSF
Advances in Experimental Medicine and Biology
2013

Quantivirus HPV E6/E7 RNA 3.0 assay (bDNA) is as sensitive, but less specific than Hybrid Capture 2 test

2013

Quantivirus HPV E6/E7 RNA 3.0 assay (bDNA) is as sensitive, but less specific than Hybrid Capture 2 test

2013

Quantivirus (R) Hpv E6/E7 Rna 3.0 Assay (Bdna) Is as Sensitive, But Less Specific Than Hybrid Capture 2 Test

2013

Quantivirus (R) Hpv E6/E7 Rna 3.0 Assay (Bdna) Is as Sensitive, But Less Specific Than Hybrid Capture 2 Test (Vol 187, Pg 288, 2013)

2013

NCI-RTOG translational program strategic guidelines for the early-stage development of radiosensitizers
Journal of the National Cancer Institute
2013

Maternal bias in mouse radiosensitivity: the role of the mitochondrial PTP
Advances in Experimental Medicine and Biology
2013

Lessons learned from radiation oncology clinical trials
Clinical Cancer Research
2013

Lessons Learned From Radiation Oncology Clinical Trials
Clinical Cancer Research
2013

Investigations of antioxidant-mediated protection and mitigation of radiation-induced DNA damage and lipid peroxidation in murine skin
International Journal of Radiation Biology
2013

Investigations of Antioxidant-Mediated Protection and Mitigation of Radiation-Induced Dna Damage and Lipid Peroxidation in Murine Skin
International Journal of Radiation Biology
2013

Interleukin 11 protects bone marrow mitochondria from radiation damage
Advances in Experimental Medicine and Biology
2013

Initial Outcomes From a Single Institution Experience With Stereotactic Ablative Radiation Therapy (Sabr) for Oligometastases
International Journal Of Radiation Oncology Biology Physics
2013

In vitro Sirius Red collagen assay measures the pattern shift from soluble to deposited collagen
Advances in Experimental Medicine and Biology
2013

In Vitro Sirius Red Collagen Assay Measures the Pattern Shift From Soluble To Deposited Collagen

2013

Improving Mucosal Function Mitigates Radiation-Induced Gastrointestinal Toxicity
The FASEB's Journal
2013

Fibroblast growth factor-peptide promotes bone marrow recovery after irradiation
Advances in Experimental Medicine and Biology
2013

Fibroblast Growth Factor-Peptide Promotes Bone Marrow Recovery After Irradiation

2013

Amifostine acts upon mitochondria to stimulate growth of bone marrow and regulate cytokines
Advances in Experimental Medicine and Biology
2013

Amifostine acts upon mitochondria to stimulate growth of bone marrow and regulate cytokines
Advances in Experimental Medicine and Biology
2013

Alteration of the inflammatory molecule network after irradiation of soft tissue
Advances in Experimental Medicine and Biology
2013

Alteration of the Inflammatory Molecule Network After Irradiation of Soft Tissue

2013

Alteration of plasma galactose/N-acetylgalactosamine level after irradiation
Advances in Experimental Medicine and Biology
2013

Alteration of circulating mitochondrial DNA concentration after irradiation
Advances in Experimental Medicine and Biology
2013

Alteration of Plasma Galactose/N-Acetylgalactosamine Level After Irradiation

2013

Alteration of Circulating Mitochondrial Dna Concentration After Irradiation

2013

Transition pattern and mechanism of B-lymphocyte precursors in regenerated mouse bone marrow after subtotal body irradiation
PLOS One
2012

Transition Pattern and Mechanism of B-Lymphocyte Precursors in Regenerated Mouse Bone Marrow After Subtotal Body Irradiation
PLOS One
2012

The Impact of Radiation-Induced Up-Regulations of Ifn-Gamma On Local Tumor Control of Malignant Melanoma in Vivo
International Journal Of Radiation Oncology Biology Physics
2012

The Antitumor Effects of Mrx102: Novel, Potent, and Synergistic
International Journal Of Radiation Oncology Biology Physics
2012

Response patterns of cytokines/chemokines in two murine strains after irradiation
Cytokine
2012

Response Patterns of Cytokines/Chemokines in Two Murine Strains After Irradiation
Cytokine
2012

Radiotherapy for liver metastases: a review of evidence
International Journal Of Radiation Oncology Biology Physics
2012

Radiotherapy for Liver Metastases: a Review of Evidence
International Journal Of Radiation Oncology Biology Physics
2012

Radiation-Induced Elevation of Plasma Dna in Mice Is Associated With Genomic Background

2012

Radiation-Induced Elevation of Plasma DNA in Mice is Associated with Genomic Background
Advances in Experimental Medicine and Biology
2012

Outcomes of Nasal Cavity and Paranasal Sinus Cancers Treated With Proton Therapy
International Journal Of Radiation Oncology Biology Physics
2012

Oncology Scan - Gastrointestinal Cancer Reply
International Journal Of Radiation Oncology Biology Physics
2012

Oligometastases Treated With Stereotactic Body Radiotherapy: Long-Term Follow-Up of Prospective Study
International Journal Of Radiation Oncology Biology Physics
2012

Nci-Rtog Translational-Program Strategic Guidelines for the Early Stage Development of Radiosensitizers
International Journal Of Radiation Oncology Biology Physics
2012

In reply to Zagar and Marks
International Journal Of Radiation Oncology Biology Physics
2012

Delayed effects of radiation on mitochondrial DNA in radiation-sensitive organs
Advances in Experimental Medicine and Biology
2012

Delayed Effects of Radiation On Mitochondrial Dna in Radiation-Sensitive Organs

2012

Cetuximab plus cisplatin, irinotecan, and thoracic radiotherapy as definitive treatment for locally advanced, unresectable esophageal cancer: a phase-II study of the SWOG (S0414)
Journal of Thoracic Oncology
2012

An international survey on liver metastases radiotherapy
Acta Oncologica
2012

An International Survey On Liver Metastases Radiotherapy
Acta Oncologica
2012

A patient alignment solution for lung SBRT setups based on a deformable registration technique
Medical Physics
2012

A Potent Amino Acid Mixture To Mitigate Radiation-Induced Gastrointestinal Toxicity
International Journal Of Radiation Oncology Biology Physics
2012

A Patient Alignment Solution for Lung Sbrt Setups Based On a Deformable Registration Technique
International Journal Of Radiation Oncology Biology Physics
2012

Triptolide Mitigates Radiation-Induced Pulmonary Fibrosis and Its Action Mechanism
International Journal Of Radiation Oncology Biology Physics
2011

Radiation decreases murine small intestinal HCO(3)(-) secretion
International Journal of Radiation Biology
2011

Radiation Decreases Murine Small Intestinal Hco(3)(-) Secretion
International Journal of Radiation Biology
2011

Proton Therapy of Esthesioneuroblastoma: the Ufpti Experience
International Journal Of Radiation Oncology Biology Physics
2011

Prospective randomized double-blind pilot study of site-specific consensus atlas implementation for rectal cancer target volume delineation in the cooperative group setting
International Journal Of Radiation Oncology Biology Physics
2011

Phase I/II trial of a COX-2 inhibitor with limited field radiation for intermediate prognosis patients who have locally advanced non-small-cell lung cancer: radiation therapy oncology group 0213
Clinical Lung Cancer
2011

Paracellular Ion Selectivity Parallels Loss of Mucosal Barrier Following Irradiation
International Journal Of Radiation Oncology Biology Physics
2011

Monitoring Tumor Radiation Response With Released Dna in Murine Models
International Journal Of Radiation Oncology Biology Physics
2011

Glycyrrhetinic Acid Protects Lungs From Radiation-Induced Toxicity
International Journal Of Radiation Oncology Biology Physics
2011

Fibroblast Growth Factor-Peptide Improves Barrier Function and Proliferation in Human Keratinocytes After Radiation
International Journal Of Radiation Oncology Biology Physics
2011

Fibroblast Growth Factor-Peptide Improves Barrier Function and Proliferation in Human Keratinocytes After Radiation
International Journal Of Radiation Oncology Biology Physics
2011

Elevated Mitochondrial Dna Copy Number and Pol-Gamma Expression But Decreased Expression of Tfam in Murine Intestine Following Therapeutic Dose Irradiation

2011

Elevated Mitochondrial DNA Copy Number and POL Expression but Decreased Expression of TFAM in Murine Intestine Following Therapeutic Dose Irradiation
Advances in Experimental Medicine and Biology
2011

Early Upsurge of Cell Free Alu Dna Predicts Declining Long-Term Graft Survival.
American Journal of Transplantation
2011

Decreasing the adverse effects of cancer therapy: National Cancer Institute guidance for the clinical development of radiation injury mitigators
Clinical Cancer Research
2011

Decreasing the Adverse Effects of Cancer Therapy: National Cancer Institute Guidance for the Clinical Development of Radiation Injury Mitigators
Clinical Cancer Research
2011

Consideration of dose limits for organs at risk of thoracic radiotherapy: atlas for lung, proximal bronchial tree, esophagus, spinal cord, ribs, and brachial plexus
International Journal Of Radiation Oncology Biology Physics
2011

Consideration of Dose Limits for Organs At Risk of Thoracic Radiotherapy: Atlas for Lung, Proximal Bronchial Tree, Esophagus, Spinal Cord, Ribs, and Brachial Plexus
International Journal Of Radiation Oncology Biology Physics
2011

Comparison of Outcomes in Patients with Stage III versus Limited Stage IV Non-Small Cell Lung Cancer
Radiation Oncology
2011

Comparison of Outcomes in Patients With Stage III Versus Limited Stage IV Non-Small Cell Lung Cancer
Radiation Oncology
2011

Combination therapy for renal cell cancer: what are possible options?
Oncology
2011

Combination Therapy for Renal Cell Cancer: What Are Possible Options?
Oncology
2011

Combination Therapy for Renal Cell Cancer: What Are Possible Options?
Oncology
2011

Antioxidant properties of select radiation mitigators based on semicarbazone and pyrazole derivatives of curcumin
Advances in Experimental Medicine and Biology
2011

Antioxidant properties of quercetin
Advances in Experimental Medicine and Biology
2011

Antioxidant Properties of Select Radiation Mitigators Based On Semicarbazone and Pyrazole Derivatives of Curcumin

2011

Antioxidant Properties of Quercetin

2011

An approach for online evaluations of dose consequences caused by small rotational setup errors in intracranial stereotactic radiation therapy
Medical Physics
2011

An Approach for Online Evaluations of Dose Consequences Caused By Small Rotational Setup Errors in Intracranial Stereotactic Radiation Therapy

2011

Testicular cancer survivorship: research strategies and recommendations
Journal of the National Cancer Institute
2010

Patterns of recurrence after curative-intent radiation for oligometastases confined to one organ
American Journal of Clinical Oncology
2010

Patterns and Timing of Recurrence After Temozolomide-Based Chemoradiation for Glioblastoma
International Journal Of Radiation Oncology Biology Physics
2010

Mitigation effect of an FGF-2 peptide on acute gastrointestinal syndrome after high-dose ionizing radiation
International Journal Of Radiation Oncology Biology Physics
2010

Animal models for medical countermeasures to radiation exposure
Radiation Research
2010

A new biodosimetric method: branched DNA-based quantitative detection of B1 DNA in mouse plasma
British Journal of Radiology
2010

Stereotactic radiosurgery for spinal metastases: Case report and review of treatment options
Bone
2009

Stereotactic radiosurgery for glioblastoma: retrospective analysis
Radiation Oncology
2009

Stereotactic Body Radiotherapy for Treatment of Adrenal Metastases
International Journal Of Radiation Oncology Biology Physics
2009

Report from the Radiation Therapy Committee of the Southwest Oncology Group (SWOG): Research Objectives Workshop 2008
Clinical Cancer Research
2009

Replication of murine mitochondrial DNA following irradiation
Advances in Experimental Medicine and Biology
2009

Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database study
Journal of Neurooncology
2009

Oligometastatic breast cancer treated with curative-intent stereotactic body radiation therapy

2009

Current developments in the radiotherapy approach to elderly and frail patients with glioblastoma multiforme
Expert Review of Anticancer Therapy
2009

Central thoracic lesions treated with hypofractionated stereotactic body radiotherapy
Radiotherapy and Oncology
2009

B1 sequence-based real-time quantitative PCR: a sensitive method for direct measurement of mouse plasma DNA levels after gamma irradiation
International Journal Of Radiation Oncology Biology Physics
2009

B1 sequence-based real-time quantitative PCR: A sensitive method for direct measurement of mouse plasma DNA levels after gamma irradiation
International Journal Of Radiation Oncology Biology Physics
2009

B1 sequence-based real-time quantitative PCR: A sensitive method for direct measurement of mouse plasma DNA levels after gamma irradiation
International Journal Of Radiation Oncology Biology Physics
2009

Analysis of patients with oligometastases undergoing two or more curative-intent stereotactic radiotherapy courses
International Journal Of Radiation Oncology Biology Physics
2009

Protein kinase A RI-alpha predicts for prostate cancer outcome: analysis of radiation therapy oncology group trial 86-10
International Journal Of Radiation Oncology Biology Physics
2008

Normal tissue toxicity after small field hypofractionated stereotactic body radiation
Radiation Oncology
2008

Molecular markers of radiation-related normal tissue toxicity
Cancer and Metastasis Reviews
2008

Medical countermeasures for radiation combined injury: radiation with burn; blast; trauma and/or sepsis. report of an NIAID Workshop
Radiation Research
2008

Evidence that MR diffusion tensor imaging (tractography) predicts the natural history of regional progression in patients irradiated conformally for primary brain tumors
International Journal Of Radiation Oncology Biology Physics
2008

Descriptive analysis of oligometastatic lesions treated with curative-intent stereotactic body radiotherapy
International Journal Of Radiation Oncology Biology Physics
2008

Antioxidants reduce consequences of radiation exposure
Advances in Experimental Medicine and Biology
2008

Anti-cancer effect of resveratrol is associated with induction of apoptosis via a mitochondrial pathway alignment
Advances in Experimental Medicine and Biology
2008

A prospective pilot study of curative-intent stereotactic body radiation therapy in patients with 5 or fewer oligometastatic lesions

2008

Triptolide alters mitochondrial functions
Advances in Experimental Medicine and Biology
2007

Normal tissue tolerance dose metrics for radiation therapy of major organs
Seminars in Radiation Oncology
2007

Lung metastases detection in CT images using 3D template matching
Medical Physics
2007

Intratumoral VEGF and FGF1 administration alters tumor growth; vascular density; oxygenation; and expression of MCP-1 and interleukins
Advances in Experimental Medicine and Biology
2007

Immunohistochemical Identification and Localization of Endogenous Endostatin and its Related Peptides in Murine Tumors
Advances in Experimental Medicine and Biology
2007

Hypofractionated stereotactic body radiation therapy (SBRT) for limited hepatic metastases
International Journal Of Radiation Oncology Biology Physics
2007

Enhanced antitumor effect of combined triptolide and ionizing radiation
Clinical Cancer Research
2007

Stereotactic Body Radiation Therapy (SBRT) for lung metastases
Acta Oncologica
2006

Protective effect of esculentoside A on radiation-induced dermatitis and fibrosis
International Journal Of Radiation Oncology Biology Physics
2006

Introduction
Seminars in Radiation Oncology
2006

Interleukin 1beta (IL1B) signaling is a critical component of radiation-induced skin fibrosis
Radiation Research
2006

Design of multi-institutional and cooperative group studies of SBRT
Acta Oncologica
2006

Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines
International Journal Of Radiation Oncology Biology Physics
2006

Bcl-2 and bax expression and prostate cancer outcome in men treated with radiotherapy in Radiation Therapy Oncology Group protocol 86-10
International Journal Of Radiation Oncology Biology Physics
2006

Tumor Detection in vivo with Optical Spectroscopy
Conference Proceedings of the IEEE Engineering in Medicine and Biology Society
2005

Regulation of prostaglandin E2 synthesis after brain irradiation
International Journal Of Radiation Oncology Biology Physics
2005

Past; present; and future of oxygen in cancer research
Advances in Experimental Medicine and Biology
2005

Occurrence; severity; and longitudinal course of twelve common symptoms in 1129 consecutive patients during radiotherapy for cancer
Journal of Pain and Symptom Management
2005

Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors
International Journal Of Radiation Oncology Biology Physics
2005

MDM2 as a predictor of prostate carcinoma outcome: an analysis of Radiation Therapy Oncology Group Protocol 8610

2005

Interleukin (IL)-1A and IL-6: applications to the predictive diagnostic testing of radiation pneumonitis
International Journal Of Radiation Oncology Biology Physics
2005

In Vivo optical Spectroscopy of Acoustically Induced Blood Stasis
Conference Proceedings of the IEEE Engineering in Medicine and Biology Society
2005

Hypoxia-induced alterations in hyaluronan and hyaluronidase
Advances in Clinical and Experimental Medicine
2005

Frequency; severity; clinical course; and correlates of fatigue in 372 patients during 5 weeks of radiotherapy for cancer

2005

Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of Radiation Therapy Oncology Group 93-05 protocol
International Journal Of Radiation Oncology Biology Physics
2004

Radiation and third-generation chemotherapy
Hematology/Oncology Clinics of North America
2004

Pentoxifylline in the treatment of radiation-induced fibrosis
Journal of Clinical Oncology
2004

Mutant; wild type; or overall p53 expression: freedom from clinical progression in tumours of astrocytic lineage
British Journal of Cancer
2004

Long-term management of patients with multiple brain metastases after shaped beam radiosurgery. Case report and review of the literature
Journal of Neurosurgery
2004

Is there a favorable subset of patients with prostate cancer who develop oligometastases?
International Journal Of Radiation Oncology Biology Physics
2004

Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model
Radiation Research
2004

fMRI for monitoring dynamic changes in tissue oxygenation/blood flow: potential applications for tumor response to carbogen treatment
Advances in Experimental Medicine and Biology
2003

Translational research in lung cancer
Seminars in Radiation Oncology
2003

The biological basis of a comprehensive grading system for the adverse effects of cancer treatment
Seminars in Radiation Oncology
2003

Role of the Recruited Bone Marrow-Derived Alveolar Macrophage and the Chemokine Receptor; CCR2 in the Development of Pulmonary Late Radiation effects in a Mouse Model
International Journal Of Radiation Oncology Biology Physics
2003

Radiation Oncology Committee of the Southwest Oncology Group. Report from the Radiation Oncology Committee of the Southwest Oncology Group (SWOG): Research Objectives Workshop 2003
American Journal of Clinical Oncology
2003

Phase I/II clinical study of pulsed paclitaxel radiosensitization for thoracic malignancy: a therapeutic approach on the basis of preclinical research of human cancer cell lines
Clinical Cancer Research
2003

Optimal marker placement in photogrammetry patient positioning system
Medical Physics
2003

Molecular (functional) imaging for radiotherapy applications: an RTOG symposium
International Journal Of Radiation Oncology Biology Physics
2003

Low-dose radiosurgery for benign intracranial lesions
American Journal of Clinical Oncology
2003

Loss of p16 expression is of prognostic significance in locally advanced prostate cancer: an analysis from the Radiation Therapy Oncology Group protocol 86-10
Journal of Clinical Oncology
2003

Fibroblast growth factors (FGFS) increase breast tumor growth rate, metastases, blood flow, and oxygenation without significant change in vascular density
Advances in Experimental Medicine and Biology
2003

FGF1 not VEGF Transfection induces in-vitro Radiation Resistance; in-vivo Radiation Modifying Effects of Angiogenic Peptides probably Relate more to Vascularity than apoptosis
International Journal Of Radiation Oncology Biology Physics
2003

FGF1 and VEGF mediated angiogenesis in KHT tumor-bearing mice
Advances in Experimental Medicine and Biology
2003

Evidence for and against hypoxia as the primary cause of tumor aggressiveness
Advances in Experimental Medicine and Biology
2003

Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth
American Journal of Clinical Oncology
2003

Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor
American Journal of Clinical Oncology
2003

A new intrinsic hypoxia marker in esophageal cancer
Advances in Experimental Medicine and Biology
2003

Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes
Radiation Research
2002

Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families
Radiation Research
2002

Radiation pneumonitis and early circulatory cytokine markers
Seminars in Radiation Oncology
2002

Comparison and modulation of angiogenic responses by FGFs, VEGF and SCF in murine and human fibrosarcomas

2002

Benefits of external beam irradiation for peripheral arterial bypass: preliminary report on a phase I study
International Journal Of Radiation Oncology Biology Physics
2002

The role of autocrine growth factors in radiation damage to the epiphyseal growth plate
Radiation Research
2001

Schedule-dependent pulsed paclitaxel radiosensitization for thoracic malignancy
American Journal of Clinical Oncology
2001

Radiation Therapy Oncology Group. Research Plan 2002-2006. Tumor Utilization Committee
International Journal Of Radiation Oncology Biology Physics
2001

Radiation Therapy Oncology Group. Research Plan 2002-2006. Translational Research Program
International Journal Of Radiation Oncology Biology Physics
2001

Radiation Therapy Oncology Group. Research Plan 2002-2006. Outcomes Committee
International Journal Of Radiation Oncology Biology Physics
2001

Predictive value of histologic tumor necrosis after radiation
International Journal of Cancer
2001

Keratinocyte growth factors radioprotect bowel and bone marrow but not KHT sarcoma
American Journal of Clinical Oncology
2001

Keratinocyte growth factors radioprotect bowel and bone marrow but not KHT sarcoma
American Journal of Clinical Oncology
2001

Intratumoral administration of endostatin plasmid inhibits vascular growth and perfusion in MCa-4 murine mammary carcinomas
Cancer Research
2001

External beam irradiation for inhibition of intimal hyperplasia following prosthetic bypass: preliminary results

2001

Erythrocyte membrane ATP binding cassette (ABC) proteins: MRP1 and CFTR as well as CD39 (ecto-apyrase) involved in RBC ATP transport and elevated blood plasma ATP of cystic fibrosis
Blood Cells, Molecules & Diseases
2001

Circulating IL-6 as a predictor of radiation pneumonitis
International Journal Of Radiation Oncology Biology Physics
2001

Characterization of the effects of antiangiogenic agents on tumor pathophysiology
American Journal of Clinical Oncology
2001

Cellular and biophysical evidence for interactions between adenosine triphosphate and P-glycoprotein substrates: functional implications for adenosine triphosphate/drug cotransport in P-glycoprotein overexpressing tumor cells and in P-glycoprotein low-level expressing erythrocytes
Blood Cells, Molecules & Diseases
2001

Multi-objective optimization in radiotherapy: applications to stereotactic radiosurgery and prostate brachytherapy
Artificial Intelligence in Medicine
2000

Irradiation for intimal hyperplasia: implications for peripheral arterial bypass
Journal of the American College of Surgeons
2000

Radiation inhibition of arterial restenosis -- a new frontier
Acta Oncologica
1999

Intraoperative optimized inverse planning for prostate brachytherapy: early experience
International Journal Of Radiation Oncology Biology Physics
1999

Comparability of the external vs internal location of radiation in inhibiting neointimal hyperplasia
Cardiovascular Radiation Medicine
1999

Circulating basic fibroblast growth factor declines during Cy/TBI bone marrow transplantation
Bone Marrow Transplantation
1999

Automated treatment planning engine for prostate seed implant brachytherapy
International Journal Of Radiation Oncology Biology Physics
1999

Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: results of a phase II prospective trial
Journal of Neurosurgery
1999

Selection of local therapy after neoadjuvant chemotherapy in patients with stage IIIA;B breast cancer
Annals of Surgical Oncology
1998

Response during radiotherapy may be associated with outcome in mediastinal Hodgkin's disease
Radiation oncology investigations
1998

Radiation-induced changes in bone perfusion and angiogenesis
International Journal Of Radiation Oncology Biology Physics
1998

Intravenous delivery of 5'-iododeoxyuridine during hyperfractionated radiotherapy for locally advanced head and neck cancers: results of a pilot study
The Laryngoscope
1998

In vivo radioprotective effects of angiogenic growth factors on the small bowel of C3H mice
Radiation Research
1998

Hyperbaric oxygen and basic fibroblast growth factor promote growth of irradiated bone
International Journal Of Radiation Oncology Biology Physics
1998

Head and neck compensation for total body irradiation using opposed laterals
Medical Dosimetry
1998

Chronic radiation bone toxicity is associated with decreased perfusion without elevation of circulating or soft tissue TGF beta or TNF alpha
Advances in Experimental Medicine and Biology
1998

Radioprotection of hematopoietic tissue by fibroblast growth factors in fractionated radiation experiments
Acta Oncologica
1997

Phase I trial of photodynamic therapy in the treatment of recurrent superficial transitional cell carcinoma of the bladder
Urology
1997

Outcome of patients with small-cell lung cancer during 20 years of clinical research at the US National Cancer Institute

1997

Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives
Cancer Research
1997

Depletion of T lymphocytes with immunotoxin retards the progress of experimental allergic encephalomyelitis in rhesus monkeys
Cellular Immunology
1997

Cystic fibrosis transmembrane conductance regulator and adenosine triphosphate
Science
1997

Breast-conserving therapy vs mastectomy in early-stage breast cancer: a meta-analysis of 10-year survival
Cancer Journal from Scientific American
1997

Acidic fibroblast growth factor (FGF1) increases survival and haematopoietic recovery in total body irradiated C3H/HeNCr mice
Cytokine
1997

Tumor growth and tumor radiosensitivity in mice given myeloprotective doses of fibroblast growth factors
Journal of the National Cancer Institute
1996

Oxygen distributions partly explain the radiation response of human squamous cell carcinomas
British Journal of Cancer
1996

MRI efficacy and effectiveness research: who needs it and who pays for it?
Journal of Magnetic Resonance Imaging
1996

Dosimetric results from a feasibility study of a novel radiosurgical source for irradiation of intracranial metastases
International Journal Of Radiation Oncology Biology Physics
1996

Differential radioprotection of three mouse strains by basic or acidic fibroblast growth factor
British Journal of Cancer
1996

Cystic fibrosis hetero- and homozygosity is associated with inhibition of breast cancer growth
Nature Medicine
1996

An approach to dose measurement for total body irradiation
International Journal Of Radiation Oncology Biology Physics
1996

A new miniature x-ray device for interstitial radiosurgery: dosimetry
Medical Physics
1996

Towards noninvasive human tumor physiologic measurements
International Journal Of Radiation Oncology Biology Physics
1995

Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer
New England Journal of Medicine
1995

Risk of second aerodigestive cancers increases in patients who survive free of small-cell lung cancer for more than 2 years
Journal of Clinical Oncology
1995

Response of non-Hodgkin lymphoma to radiation therapy: early and long-term assessment with H-1 MR spectroscopic imaging
Radiology
1995

Radiation dose-response of human tumors
International Journal Of Radiation Oncology Biology Physics
1995

Long-term visual changes following pituitary irradiation
International Journal Of Radiation Oncology Biology Physics
1995

Effect of intraperitoneal ATP on tumor growth and bone marrow radiation tolerance
Acta Oncologica
1995

Dosimetric considerations in treating mediastinal disease with mantle fields: characterization of the dose under mantle blocks
International Journal Of Radiation Oncology Biology Physics
1995

Basic fibroblast growth factor radioprotects bone marrow and not RIF1 tumor
Acta Oncologica
1995

Treatment of locally advanced cancer of the head and neck with 5'-iododeoxyuridine and hyperfractionated radiation therapy: measurement of cell labeling and thymidine replacement
Journal of the National Cancer Institute
1994

The role of oxygen tension distribution on the radiation response of human breast carcinoma
Advances in Experimental Medicine and Biology
1994

Intracellular acidosis in murine fibrosarcomas coincides with ATP depletion, hypoxia, and high levels of lactate and total Pi
NMR in Bioscience
1994

Functional cerebral imaging in the evaluation and radiotherapeutic treatment planning of patients with malignant glioma
International Journal Of Radiation Oncology Biology Physics
1994

1H-NMR measurement of fractional dissociation of imidazole in intact animals
American Journal of Physiology
1994

Radiosensitivity in vitro of human soft tissue sarcoma cell lines and skin fibroblasts derived from the same patients
International Journal of Radiation Biology
1993

Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone
International Journal Of Radiation Oncology Biology Physics
1993

Intrinsic radiation sensitivity may not be the major determinant of the poor clinical outcome of glioblastoma multiforme
International Journal Of Radiation Oncology Biology Physics
1993

13C- and 31P-NMR studies of human colon cancer in-vitro and in-vivo
Surgical Oncology
1993

Oxygenation of mammary tumors: from isotransplanted rodent tumors to primary malignancies in patients
Advances in Experimental Medicine and Biology
1992

Oxygenation and bioenergetic status of murine fibrosarcomas
Advances in Experimental Medicine and Biology
1992

Measurements of tumor blood flow using intraperitoneal deuterium and 2H-NMR spectroscopy
Advances in Experimental Medicine and Biology
1992

Measurement of human tumor blood flow: a positron technique using an artifact of high energy radiation therapy
Advances in Experimental Medicine and Biology
1992

Clinical implications of heterogeneity of tumor response to radiation therapy
Radiotherapy and Oncology
1992

Tumors growing in irradiated tissue: oxygenation, metabolic state, and pH
International Journal Of Radiation Oncology Biology Physics
1991

The life shortening effects of treatment with doxorubicin and/or local irradiation on a cohort of young C3Hf/Sed mice
European Journal of Cancer
1991

Interactions between ascorbic acid and the radiation of bone marrow, skin, and tumor
American Journal of Clinical Nutrition
1991

Blood flow of human soft tissue sarcomas measured by thallium-201 scanning: prediction of tumor response to radiation
International Journal Of Radiation Oncology Biology Physics
1991

Angiogenesis determines blood flow, metabolism, growth rate, and ATPase kinetics of tumors growing in an irradiated bed: 31P and 2H nuclear magnetic resonance studies
Cancer Research
1991

Lack of efficacy of water-suppressed proton nuclear magnetic resonance spectroscopy of plasma for the detection of malignant tumors
New England Journal of Medicine
1990

Interaction of oxygen partial pressure and energy metabolism with the relaxation rate of inorganic phosphate: a 31P NMR study
Advances in Experimental Medicine and Biology
1990

In vivo 31P-NMR spectroscopy of murine tumours before and after localized hyperthermia
International Journal of Hyperthermia
1990

Fractionation sensitivity and immunological status in radiation treated murine sarcomas
International Journal Of Radiation Oncology Biology Physics
1990

Failure of 1H nuclear magnetic resonance spectroscopy of blood plasma to detect malignancy
Journal of Clinical Oncology
1990

Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSall tumors
Cancer Research
1990

Detection of malignant tumors by 1H nuclear magnetic resonance spectroscopy of plasma
European Journal of Cancer
1990

Blood flow, oxygen consumption and tissue oxygenation of human tumors
Advances in Experimental Medicine and Biology
1990

Response of tumour red blood cell flux to hyperthermia and/or hyperglycaemia
International Journal of Hyperthermia
1989

Radiation therapy in the treatment of difficult giant cell tumors
International Journal Of Radiation Oncology Biology Physics
1989

Evaluation of tumor energy metabolism and microvascular blood flow after glucose or mannitol administration using 31P nuclear magnetic resonance spectroscopy and laser Doppler flowmetry
International Journal Of Radiation Oncology Biology Physics
1989

Effects of hypothermia on rat brain pHi and phosphate metabolite regulation by 31P-NMR
Journal of Applied Physiology
1989

Effects of hypercapnia on brain pHi and phosphate metabolite regulation by 31P-NMR
Journal of Applied Physiology
1989

Effects of hydralazine on in vivo tumor energy metabolism, hematopoietic radiation sensitivity, and cardiovascular parameters
International Journal Of Radiation Oncology Biology Physics
1989

Effect of intraperitoneal versus intravenous glucose administration on laser Doppler flow in murine FSaII tumors and normal skin
Cancer Research
1989

Correlations between 31P-NMR spectroscopy and tissue O2 tension measurements in a murine fibrosarcoma
Radiation Research
1989

Blood flow, tissue oxygenation, pH distribution, and energy metabolism of murine mammary adenocarcinomas during growth
Advances in Experimental Medicine and Biology
1989

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review
Cancer Research
1989

Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts
Cancer Research
1989

31P nuclear magnetic resonance measurements of ATPase kinetics in malignant tumors
Advances in Experimental Medicine and Biology
1989

Role of hypovolemic hemoconcentration in dose-dependent flow decline observed in murine tumors after intraperitoneal administration of glucose or mannitol
Cancer Research
1988

Estimation of tumor oxygenation and metabolic rate using 31P MRS: correlation of longitudinal relaxation with tumor growth rate and DNA synthesis
International Journal Of Radiation Oncology Biology Physics
1988

Effects of pentobarbital anesthesia on the energy metabolism of murine tumors studied by in vivo 31P nuclear magnetic resonance spectroscopy
Radiation Research
1988

Effects of hydralazine-induced vasodilation on the energy metabolism of murine tumors studied by in vivo 31P-nuclear magnetic resonance spectroscopy
Journal of the National Cancer Institute
1988

Toxicity, radiation sensitivity modification, and combined drug effects of ascorbic acid with misonidazole in vivo on FSaII murine fibrosarcomas
Journal of the National Cancer Institute
1987

The effect of hyperglycemia on the tumor response to irradiation given alone or in combination with hyperthermia
Radiation Research
1987

Size dependent changes in tumor phosphate metabolism after radiation therapy as detected by 31P NMR spectroscopy
International Journal Of Radiation Oncology Biology Physics
1987

Effects of oxygen on the metabolism of murine tumors using in vivo phosphorus-31 NMR
American Journal of Clinical Oncology
1987

Effect of temperature on blood flow and hypoxic fraction in a murine fibrosarcoma
International Journal Of Radiation Oncology Biology Physics
1987

Critical Review: tumor size dependent metabolic changes in a murine fibrosarcoma: use of Fourier transform 31P NMR to evaluate tumor energy metabolism
Investigative Radiology
1987

Tumor size dependent changes in a murine fibrosarcoma: use of in vivo 31P NMR for non-invasive evaluation of tumor metabolic status
International Journal Of Radiation Oncology Biology Physics
1986

Extremity preservation by combined modality treatment of sarcomas of the hand and wrist
International Journal Of Radiation Oncology Biology Physics
1986

Research Interests

Nearly 1.6 million Americans were diagnosed with cancer last year, and nearly 600,000 died from the disease, according to the National Cancer Institute. Experts estimate that as many as 90 percent of those deaths were from metastases, when the cancer has spread from the original disease site to other organs. These data seem to support conventional wisdom about cancer -- that once it appears in a different location from where it began it is systemic, and can only be treated palliatively, usually with chemotherapy alone.

This line of thought is being challenged by some visionary oncologists who don't believe all tumors are alike. They reject the notion that a diagnosis of metastatic cancer is an automatic terminal diagnosis.

"The dogma is that this type of disease is incurable and that if there's a metastatic tumor in one organ, then others must be present throughout the body," said Paul Okunieff, M.D., director of the UF Shands Cancer Center and chairman of the UF College of Medicine's department of radiation oncology. "It's considered an all-or-none phenomenon, but the fact is, this view is probably not correct. We need to think about metastasis like we think about the primary tumor: determine how much it has spread, then decide whether it's treatable based on existing technology."

Dr. Okunieff is an international expert in the treatment of metastatic disease and has developed what we believe to be the first multidisciplinary program and clinic devoted to the treatment of metastatic disease. Dr. Roi Dagan, the program leader, will work with Dr. Okunieff to develop surgical, medical and radiation approaches for comprehensive treatment of patients with oligometastases -- or metastatic disease that in the very early stages with a few, small tumors.

This joint program between Gainesville and UF Health Proton Therapy Institute in Jacksonville will include the commissioning of a VERO system, the second in the United States. VERO allows for robotically controlled, real-time stereotactic targeting of moving objects within the body. Better targeting means that a higher dose of radiation can be delivered to the tumor with a lower dose to the adjacent normal tissue.

The clinical program will be complemented by a basic science program aimed at identifying molecular markers predictive of metastases, developing interventions that can prevent subclinical metastases from progressing, and selecting screening programs for cancer patients at high risk for oligometastases.

Dr. Okunieff thinks of the future this way: "Our new technologies can actually follow in three dimensions with sub-millimeter accuracy, and in real time, a lesion that is moving while you breathe or while your heart is beating. I have a vision, which we will be implementing soon, that our cancer patients will be treated quickly, accurately and curatively. Imagine you are the physician. A patient has a PET scan, and you find they have one new tumor. You target it, you send them into the second room, you kill it and you send them home. With that technology, before that patient even gets home, the tumor is dead -- with at least an 80% likelihood. This changes the entire dynamic. Imagine now being the cancer patient and your spouse asks: 'How did your visit go today?' And you say, 'I had one spot and they killed it. Let's have dinner.'

"It's a much better way to go home. It's very reasonable to expect and to dream that the UF Shands Cancer Center will become the pre-eminent cancer center for the treatment of metastatic disease in the country. I think we can be as great as we dream to be. And so I'm dreaming big."

Active Research Studies

Patient Testimonial

  • Living with cancer is like living with your mortality and having it always right there. I’ve never counted them, but I’d gone to a number of oncologists. I had one who told me that all I could do was palliative treatment — I would never get better. Fortunately I then saw Dr. Okunieff who told me ‘Oh no, you’ll be fine!’ We’ll just take care of this, and you’ll be fine.'

    Jane

    Silver Springs, FL