John Hiemenz, M.D.

John W Hiemenz, M.D.

(352) 733-0972

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Publications

Safety, feasibility and preliminary efficacy of single agent combretastatin A1 diphosphate (OXi4503) in patients with relapsed or refractory acute myeloid leukemia or myelodysplastic syndromes.
British journal of haematology
2020

Phase 2 Study of Anti-Human Cytomegalovirus Monoclonal Antibodies for Prophylaxis in Hematopoietic Cell Transplantation.
Antimicrobial agents and chemotherapy
2020

Melflufen and Dexamethasone in Heavily Pretreated Relapsed and Refractory Multiple Myeloma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
2020

Dietary Intake and Diet Quality of Hematopoietic Stem Cell Transplantation Survivors.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
2020

Clinical predictors of delayed engraftment in autologous hematopoietic cell transplant recipients.
Hematology/oncology and stem cell therapy
2020

Survivor and Caregiver Expectations and Preferences Regarding Lung Cancer Treatment.
International journal of particle therapy
2019

A genomics-informed computational biology platform prospectively predicts treatment responses in AML and MDS patients.
Blood advances
2019

Poor peripheral blood stem cell mobilization affects long-term outcomes in multiple myeloma patients undergoing autologous stem cell transplantation.
Journal of clinical apheresis
2018

Impact of the CYP2C19 genotype on voriconazole exposure in adults with invasive fungal infections.
Pharmacogenetics and genomics
2017

Effect of melphalan 140 mg/m(2) vs 200 mg/m(2) on toxicities and outcomes in multiple myeloma patients undergoing single autologous stem cell transplantation-a single center experience.
Clinical transplantation
2016

Association of mannose-binding lectin levels and invasive fungal disease in hematologic malignancy patients receiving myelosuppressive chemotherapy or allogeneic hematopoietic stem cell transplantation.
Bone marrow transplantation
2016

A new model to predict remission status in AML patients based on day 14 bone marrow biopsy.
Leukemia research
2016

Voriconazole therapeutic drug monitoring: results of a prematurely discontinued randomized multicenter trial.
Transplant infectious disease : an official journal of the Transplantation Society
2015

Poor Peripheral Blood Stem Cell Mobilization Correlates With Worse Long-Term Outcomes in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation
Biology of Blood and Marrow Transplantation
2015

Aztreonam for febrile neutropenia in patients with beta-lactam allergy.
Transplant infectious disease : an official journal of the Transplantation Society
2014

A Cyp2C19 Genotype Guided Dosing Approach for Optimizing Voriconazole in Patients With Ifis.
Pharmacotherapy
2014

Association of Mannose Binding Lectin (Mbl) Levels and Invasive Fungal Disease (Ifd) in Hematologic Malignancy Patients Undergoing Hematopoietic Stem Cell Transplantation (Hsct) Or Receiving Chemotherapy
Biology of Blood and Marrow Transplantation
2013

Peripheral Blood Cd34(+) Specific Donor Chimerism Analysis as An Early Indicator of Disease Relapse After Allogeneic Hematopoietic Stem Cell Transplant in Patients With Myelodysplastic Syndromes and Acute Myelogenous Leukemia.
Blood
2012

How I manage pulmonary nodular lesions and nodular infiltrates in patients with hematologic malignancies or undergoing hematopoietic cell transplantation.
Blood
2012

A Phase I Study of the Vascular Disrupting Combretastatin, Oxi4503, in Patients With Relapsed and Refractory Acute Myeloid Leukemia (Aml) and Myelodysplastic Syndromes (Mds)
Blood
2012

Hematopoietic stem cell transplantation: an overview of infection risks and epidemiology.
Hematology/oncology clinics of North America
2011

Hematopoietic stem cell transplantation: an overview of infection risks and epidemiology.
Infectious disease clinics of North America
2010

Efficacy of caspofungin as salvage therapy for invasive aspergillosis compared to standard therapy in a historical cohort.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
2010

Management of infections complicating allogeneic hematopoietic stem cell transplantation.
Seminars in hematology
2009

Population pharmacokinetics of micafungin in adult patients.
Diagnostic microbiology and infectious disease
2008

Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2006

Pharmacokinetic and maximum tolerated dose study of micafungin in combination with fluconazole versus fluconazole alone for prophylaxis of fungal infections in adult patients undergoing a bone marrow or peripheral stem cell transplant.
Antimicrobial agents and chemotherapy
2005

Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2004

Infections due to emerging and uncommon medically important fungal pathogens.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
2004

Adoptive immunotherapy with donor lymphocyte infusions and interleukin-2 after high-dose therapy and autologous stem cell rescue for multiple myeloma.
Bone marrow transplantation
2004

Amphotericin B deoxycholate administered by continuous infusion: does the dosage make a difference?
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2003

The impact of culture isolation of Aspergillus species: a hospital-based survey of aspergillosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2001

Need for alternative trial designs and evaluation strategies for therapeutic studies of invasive mycoses.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2001

Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study Group.
Medicine
2000

Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group.
The New England journal of medicine
1999

Clinical significance of nephrotoxicity in patients treated with amphotericin B for suspected or proven aspergillosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
1999

Amphotericin B lipid complex in pediatric patients with invasive fungal infections.
The Pediatric infectious disease journal
1999

A double-blind comparison of empirical oral and intravenous antibiotic therapy for low-risk febrile patients with neutropenia during cancer chemotherapy.
The New England journal of medicine
1999

Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
1998

Nocardiosis after bone marrow transplantation: a retrospective study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
1997

Nephrotoxicity of high-dose ifosfamide/carboplatin/etoposide in adults undergoing autologous stem cell transplantation.
The American journal of the medical sciences
1997

High-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with multiple myeloma and renal insufficiency.
Bone marrow transplantation
1997

Dexamethasone, cyclophosphamide, idarubicin and etoposide (DC-IE): a novel, intensive induction chemotherapy regimen for patients with high-risk multiple myeloma.
British journal of haematology
1997

Amphotericin B colloidal dispersion vs. amphotericin B as therapy for invasive aspergillosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
1997

Recent progress and current problems in treatment of invasive fungal infections in neutropenic patients.
Infectious disease clinics of North America
1996

Phase I-II study of high-dose busulfan and cyclophosphamide followed by autologous peripheral blood stem cell transplantation for hematological malignancies: toxicities and hematopoietic recovery.
Bone marrow transplantation
1996

Methylobacterium bacteremia after infusion of contaminated autologous bone marrow.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
1996

Lipid formulations of amphotericin B: recent progress and future directions.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
1996

Identification of an amphotericin B resistant strain of Candida albicans using a rapid 3H-glucose incorporation microassay.
The Journal of infection
1996

Ifosfamide, carboplatin, and etoposide: a new regimen with a broad spectrum of activity.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
1994

High-dose ifosfamide/carboplatin/etoposide: maximum tolerable doses, toxicities, and hematopoietic recovery after autologous stem cell reinfusion.
Seminars in oncology
1994

Evolving risk factors for invasive fungal infections--all neutropenic patients are not the same.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
1994

When, how, what, and where to purge are not the questions either.
Journal of hematotherapy
1993

Two novel high-dose treatment regimens for metastatic breast cancer--ifosfamide, carboplatin, plus etoposide and mitoxantrone plus thiotepa: outcomes and toxicities.
Seminars in oncology
1993

The platelet-refractory bone marrow transplant patient: prophylaxis and treatment of bleeding.
Seminars in oncology
1993

Special considerations for the patient undergoing allogeneic or autologous bone marrow transplantation.
Hematology/oncology clinics of North America
1993

Malassezia furfur folliculitis in cancer patients. The need for interaction of microbiologist, surgical pathologist, and clinician in facilitating identification by the clinical microbiology laboratory.
Annals of clinical and laboratory science
1993

Intensive dose ifosfamide, carboplatin, and etoposide followed by autologous stem cell rescue: results of a phase I/II study in breast cancer patients.
Surgical oncology
1993

Rigors with vancomycin.
Annals of internal medicine
1991

Invasive fusariosis associated with an injury by a stingray barb.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology
1990

A randomized trial of open lung biopsy versus empiric antimicrobial therapy in cancer patients with diffuse pulmonary infiltrates.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
1990

A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia.
The New England journal of medicine
1986

New beta-lactam antibiotics in granulocytopenic patients. New options and new questions.
The American journal of medicine
1985

Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies.
Annals of internal medicine
1984

Approaching the controversies in antibacterial management of cancer patients.
The American journal of medicine
1984

Research Interests

  • Dr. Hiemenz' academic interests include the diagnosis and treatment of hematological malignancies and primary bone marrow disorders, the use of hematopoietic stem cell transplantation for the treatment of malignant and non-malignant diseases, and supportive care for the patient undergoing intensive induction therapy and/or hematopoietic stem cell transplantation with particular interest in the diagnosis and management of graft versus host disease and infectious complications in the immune compromised host.

Active Research Studies