Frederick Moore, MD

Frederick A Moore, MD, FACS, MCCM

(352) 265-0535

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Publications

Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2021

The Effect of Aging Physiology on Critical Care.
Critical care clinics
2021

Distinct immunologic endotypes are associated with clinical trajectory after severe blunt trauma and hemorrhagic shock.
The journal of trauma and acute care surgery
2021

Single Cell RNA-SEQ of Human Myeloid Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets with Unique Transcriptional Responses: A Pilot Study.
Shock (Augusta, Ga.)
2020

Sequential Organ Failure Assessment Component Score Prediction of In-hospital Mortality From Sepsis.
Journal of intensive care medicine
2020

Prospective Validation of a Transcriptomic Metric in Severe Trauma.
Annals of surgery
2020

Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study.
Critical care (London, England)
2020

Persistently increased cell-free DNA concentrations only modestly contribute to outcome and host response in sepsis survivors with chronic critical illness.
Surgery
2020

Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival.
Journal of the American Geriatrics Society
2020

Is there a role for tissue plasminogen activator as a novel treatment for refractory COVID-19 associated acute respiratory distress syndrome?
The journal of trauma and acute care surgery
2020

Enteral Nutrition Administration Record (ENAR) Prescribing Process Using Computerized Order Entry: A New Paradigm and Opportunities to Improve Outcomes in Critically Ill Patients.
JPEN. Journal of parenteral and enteral nutrition
2020

Development of a Simple Sequential Organ Failure Assessment Score for Risk Assessment of Emergency Department Patients With Sepsis.
Journal of intensive care medicine
2020

Delayed interhospital transfer of critically ill patients with surgical sepsis.
The journal of trauma and acute care surgery
2020

Clinical Impact of a Dedicated Trauma Hybrid Operating Room.
Journal of the American College of Surgeons
2020

Abdominal sepsis patients have a high incidence of chronic critical illness with dismal long-term outcomes.
American journal of surgery
2020

2020 update of the WSES guidelines for the management of acute colonic diverticulitis in the emergency setting.
World journal of emergency surgery : WJES
2020

The impact of standardized protocol implementation for surgical damage control and temporary abdominal closure after emergent laparotomy.
The journal of trauma and acute care surgery
2019

The evolving role of laparoscopic lavage and drainage.
The journal of trauma and acute care surgery
2019

The Impact of Prior Laparotomy and Intra-abdominal Adhesions on Bowel and Mesenteric Injury Following Blunt Abdominal Trauma.
World journal of surgery
2019

The Development of Chronic Critical Illness Determines Physical Function, Quality of Life, and Long-Term Survival Among Early Survivors of Sepsis in Surgical ICUs.
Critical care medicine
2019

Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors.
Critical care (London, England)
2019

Persistently Elevated Glucagon-Like Peptide-1 Levels among Critically Ill Surgical Patients after Sepsis and Development of Chronic Critical Illness and Dismal Long-Term Outcomes.
Journal of the American College of Surgeons
2019

Persistent inflammation and anemia among critically ill septic patients.
The journal of trauma and acute care surgery
2019

Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.
Critical care medicine
2019

Occult bowel injury after blunt abdominal trauma.
American journal of surgery
2019

Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.
Critical care (London, England)
2019

LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock.
BMJ open
2019

Current Epidemiology of Surgical Sepsis: Discordance Between Inpatient Mortality and 1-year Outcomes.
Annals of surgery
2019

Cell-free nuclear, but not mitochondrial, DNA concentrations correlate with the early host inflammatory response after severe trauma.
Scientific reports
2019

Cardiac pseudoaneurysm following non-operative management after penetrating thoracoabdominal trauma and pericardial window.
The journal of trauma and acute care surgery
2019

2019 update of the WSES guidelines for management of Clostridioides (Clostridium) difficile infection in surgical patients.
World journal of emergency surgery : WJES
2019

The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients.
The journal of trauma and acute care surgery
2018

The effects of beta blockade and clonidine on persistent injury-associated anemia.
The Journal of surgical research
2018

Successful nonoperative management of uncomplicated appendicitis: predictors and outcomes.
The Journal of surgical research
2018

Sepsis is associated with reduced spontaneous neutrophil migration velocity in human adults.
PloS one
2018

Resuscitative Endovascular Balloon Occlusion of the Aorta: Implementation and Preliminary Results at an Academic Level I Trauma Center.
Journal of the American College of Surgeons
2018

Raising concerns about the Sepsis-3 definitions.
World journal of emergency surgery : WJES
2018

Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.
Surgery
2018

Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.
Frontiers in immunology
2018

Hypertonic saline resuscitation after emergent laparotomy and temporary abdominal closure.
The journal of trauma and acute care surgery
2018

HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock.
PloS one
2018

HDL Cholesterol Efflux is Impaired in Older Patients with Early Sepsis: A Subanalysis of a Prospective Pilot Study.
Shock (Augusta, Ga.)
2018

Geriatric traumatic brain injury-What we know and what we don't.
The journal of trauma and acute care surgery
2018

Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis.
Shock (Augusta, Ga.)
2018

Effect of Time to Operation on Value of Care in Acute Care Surgery.
World journal of surgery
2018

Chronic Critical Illness: Application of What We Know.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2018

Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.
Frontiers in immunology
2018

Can Specialized Pro-resolving Mediators Deliver Benefit Originally Expected from Fish Oil?
Current gastroenterology reports
2018

Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2017 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group.
World journal of emergency surgery : WJES
2018

Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.
The journal of trauma and acute care surgery
2018

Autophagy: should it play a role in ICU management?
Current opinion in critical care
2018

Anemia and blood transfusion in elderly trauma patients.
The Journal of surgical research
2018

A protocol for non-operative management of uncomplicated appendicitis.
The journal of trauma and acute care surgery
2018

What is the current role of laparoscopic lavage in perforated diverticulitis?
The journal of trauma and acute care surgery
2017

Western Trauma Association Critical Decisions in Trauma: Management of adult blunt splenic trauma-2016 updates.
The journal of trauma and acute care surgery
2017

The role of NIGMS P50 sponsored team science in our understanding of multiple organ failure.
The journal of trauma and acute care surgery
2017

The research agenda for trauma critical care.
Intensive care medicine
2017

The effects of red cell transfusion donor age on nosocomial infection among trauma patients.
American journal of surgery
2017

The authors reply.
Critical care medicine
2017

The Epidemiology of Chronic Critical Illness After Severe Traumatic Injury at Two Level-One Trauma Centers.
Critical care medicine
2017

The Coalition for National Trauma Research supports the call for a national trauma research action plan.
The journal of trauma and acute care surgery
2017

Temporary abdominal closure for trauma and intra-abdominal sepsis: Different patients, different outcomes.
The journal of trauma and acute care surgery
2017

Summary Points and Consensus Recommendations From the International Protein Summit
Nutrition in Clinical Practice
2017

Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.
BMJ open
2017

Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome.
Critical care medicine
2017

Routine surveillance cholangiography after percutaneous cholecystostomy delays drain removal and cholecystectomy.
The journal of trauma and acute care surgery
2017

Predicting appendiceal tumors among patients with appendicitis.
The journal of trauma and acute care surgery
2017

Postinjury Inflammation and Organ Dysfunction.
Critical care clinics
2017

Persistent, Immunosuppression, Inflammation, Catabolism Syndrome and Diaphragmatic Dysfunction
Current Pulmonology Reports
2017

Persistent Inflammation, Immunosuppression and Catabolism Syndrome.
Critical care clinics
2017

Neural network prediction of severe lower intestinal bleeding and the need for surgical intervention.
The Journal of surgical research
2017

Microbial recognition and danger signals in sepsis and trauma.
Biochimica et biophysica acta. Molecular basis of disease
2017

Managing sepsis: Electronic recognition, rapid response teams, and standardized care save lives.
Journal of critical care
2017

Improved outcomes following implementation of an acute gastrointestinal bleeding multidisciplinary protocol.
The journal of trauma and acute care surgery
2017

Human Myeloid-derived Suppressor Cells are Associated With Chronic Immune Suppression After Severe Sepsis/Septic Shock.
Annals of surgery
2017

Exploring the Predictive Ability of Dysfunctional High-Density Lipoprotein for Adverse Outcomes in Emergency Department Patients with Sepsis: A Preliminary Investigation.
Shock (Augusta, Ga.)
2017

Experimental and Outcome-Based Approaches to Protein Requirements in the Intensive Care Unit.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2017

Emergent laparotomy and temporary abdominal closure for the cirrhotic patient.
The Journal of surgical research
2017

Early bronchoalveolar lavage for intubated trauma patients with TBI or chest trauma.
Journal of critical care
2017

Computed tomography evidence of fluid in the hernia sac predicts surgical site infection following mesh repair of acutely incarcerated ventral and groin hernias.
The journal of trauma and acute care surgery
2017

Characterization of hypoalbuminemia following temporary abdominal closure.
The journal of trauma and acute care surgery
2017

Antibiotics May be Safely Discontinued Within One Week of Percutaneous Cholecystostomy.
World journal of surgery
2017

Acute Kidney Injury Following Exploratory Laparotomy and Temporary Abdominal Closure.
Shock (Augusta, Ga.)
2017

WSES classification and guidelines for liver trauma.
World journal of emergency surgery : WJES
2016

WSES Guidelines for the management of acute left sided colonic diverticulitis in the emergency setting.
World journal of emergency surgery : WJES
2016

The long-term burden of severe sepsis and septic shock: Sepsis recidivism and organ dysfunction.
The journal of trauma and acute care surgery
2016

Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock.
The journal of trauma and acute care surgery
2016

Preoperative assessment of the risk for multiple complications after surgery.
Surgery
2016

Persistent Inflammation, Immunosuppression, and Catabolism: Evolution of Multiple Organ Dysfunction.
Surgical infections
2016

Patterns of gene expression among murine models of hemorrhagic shock/trauma and sepsis.
Physiological genomics
2016

Nutritional Support in the Setting of Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (Pics)
Current Surgery Reports
2016

Intubated Trauma Patients Receiving Prolonged Antibiotics for Pneumonia despite Negative Cultures: Predictors and Outcomes.
Surgical infections
2016

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).
World journal of emergency surgery : WJES
2016

The role of the open abdomen procedure in managing severe abdominal sepsis: WSES position paper.
World journal of emergency surgery : WJES
2015

The future of murine sepsis and trauma research models.
Journal of leukocyte biology
2015

Successful implementation of a packed red blood cell and fresh frozen plasma transfusion protocol in the surgical intensive care unit.
PloS one
2015

Persistent inflammatory, immunosuppressed, catabolic syndrome (PICS): A new phenotype of multiple organ failure.
Journal of advanced nutritional and human metabolism
2015

Measuring trauma system performance: Right patient, right place-Mission accomplished?
The journal of trauma and acute care surgery
2015

Evolving paradigms in the nutritional support of critically ill surgical patients.
Current problems in surgery
2015

Cost and Mortality Associated With Postoperative Acute Kidney Injury.
Annals of surgery
2015

Clostridium difficile Infections after Blunt Trauma: A Different Patient Population?
Surgical infections
2015

Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.
Critical care (London, England)
2015

A protocol for the management of adhesive small bowel obstruction.
The journal of trauma and acute care surgery
2015

A proposal for a CT driven classification of left colon acute diverticulitis.
World journal of emergency surgery : WJES
2015

A Review of GM-CSF Therapy in Sepsis.
Medicine
2015

A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged.
Journal of immunology (Baltimore, Md. : 1950)
2015

The Lung Neutrophil Transcriptome After Trauma Influences the Worse Outcomes of the Old To Pneumonia
Critical Care Medicine
2014

Protective immunity and defects in the neonatal and elderly immune response to sepsis.
Journal of immunology (Baltimore, Md. : 1950)
2014

Postinjury abdominal compartment syndrome: from recognition to prevention.
Lancet (London, England)
2014

Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma.
The journal of trauma and acute care surgery
2014

Oesophageal injuries: Position paper, WSES, 2013.
World journal of emergency surgery : WJES
2014

Host responses to sepsis vary in different low-lethality murine models.
PloS one
2014

Gram Stain Can Be Used To Safely Discontinue Vancomycin Therapy for Early Pneumonia in the Trauma Intensive Care Unit
The American Surgeon
2014

Emergency Surgeon: 'Last of the Mohicansandquot; 2014-2016 Editorial Policy Wses-Wjes: Position Papers, Guidelines, Courses, Books and Original Research; From Wjes Impact Factor To Wses Congress Impact Factor
World journal of emergency surgery : WJES
2014

Emergency Surgeon: 'Last of the Mohicansandquot; 2014-2016 Editorial Policy Wses-Wjes: Position Papers, Guidelines, Courses, Books and Original Research; From Wjes Impact Factor To Wses Congress Impact Factor (Vol 9, Pg 25, 2014)
World journal of emergency surgery : WJES
2014

Current concept of abdominal sepsis: WSES position paper.
World journal of emergency surgery : WJES
2014

Computer versus paper system for recognition and management of sepsis in surgical intensive care.
The journal of trauma and acute care surgery
2014

Blunt cerebrovascular injury in rugby and other contact sports: case report and review of the literature.
World journal of emergency surgery : WJES
2014

Aged mice are unable to mount an effective myeloid response to sepsis.
Journal of immunology (Baltimore, Md. : 1950)
2014

A better understanding of why murine models of trauma do not recapitulate the human syndrome.
Critical care medicine
2014

A Novel Drug for Treatment of Necrotizing Soft-Tissue Infections: A Randomized Clinical Trial.
JAMA surgery
2014

A Comparison of the Leukocyte Genomic Responses To Sterile Or Infectious Inflammation
Shock
2014

Wses Guidelines for Emergency Repair of Complicated Abdominal Wall Hernias
World journal of emergency surgery : WJES
2013

Western Trauma Association critical decisions in trauma: penetrating neck trauma.
The journal of trauma and acute care surgery
2013

Western Trauma Association critical decisions in trauma: management of pancreatic injuries.
The journal of trauma and acute care surgery
2013

Western Trauma Association critical decisions in trauma: evaluation and management of peripheral vascular injury, part II.
The journal of trauma and acute care surgery
2013

Second Wses Convention, Wjes Impact Factor, and Emergency Surgery Worldwide
World journal of emergency surgery : WJES
2013

Re: Mandatory exploration is not necessary for patients with acute diverticulitis and free intraperitoneal air.
The journal of trauma and acute care surgery
2013

Position paper: management of perforated sigmoid diverticulitis.
World journal of emergency surgery : WJES
2013

National surgical quality improvement program underestimates the risk associated with mild and moderate postoperative acute kidney injury.
Critical care medicine
2013

Just say no to intensive care unit starvation: a nutrition education program for surgery residents.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2013

Is There Value in Plasma Cytokine Measurements in Patients With Severe Trauma and Sepsis?
Methods
2013

Identification and description of a novel murine model for polytrauma and shock.
Critical care medicine
2013

Early diagnosis and evidence-based care of surgical sepsis.
Journal of intensive care medicine
2013

Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2013 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group.
World journal of emergency surgery : WJES
2013

Acute kidney injury is surprisingly common and a powerful predictor of mortality in surgical sepsis.
The journal of trauma and acute care surgery
2013

Acute kidney injury is associated with early cytokine changes after trauma.
The journal of trauma and acute care surgery
2013

A genomic analysis of Clostridium difficile infections in blunt trauma patients.
The journal of trauma and acute care surgery
2013

2013 WSES guidelines for management of intra-abdominal infections.
World journal of emergency surgery : WJES
2013

Western Trauma Association critical decisions in trauma: resuscitative thoracotomy.
The journal of trauma and acute care surgery
2012

Western Trauma Association critical decisions in trauma: management of the mangled extremity.
The journal of trauma and acute care surgery
2012

Western Trauma Association critical decisions in trauma: management of parapneumonic effusion.
The journal of trauma and acute care surgery
2012

Western Trauma Association critical decisions in trauma: management of complicated diverticulitis.
The journal of trauma and acute care surgery
2012

The identification of thyroid dysfunction in surgical sepsis.
The journal of trauma and acute care surgery
2012

TNFR1-dependent pulmonary apoptosis during ischemic acute kidney injury.
American journal of physiology. Lung cellular and molecular physiology
2012

Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care.
The journal of trauma and acute care surgery
2012

Identification and Description of a Novel Murine Model for Polytrauma and Shock
Shock
2012

Epidemiology of sepsis in surgical patients.
The Surgical clinics of North America
2012

Effect of Postoperative Acute Kidney Injury On Hospital Cost
Critical Care Medicine
2012

Western Trauma Association/critical decisions in trauma: operative management of adult blunt hepatic trauma.
The Journal of trauma
2011

WSES consensus conference: Guidelines for first-line management of intra-abdominal infections.
World journal of emergency surgery : WJES
2011

The use of lactated ringer's in shock resuscitation: the good, the bad and the ugly.
The Journal of trauma
2011

The epidemiology of sepsis in general surgery patients.
The Journal of trauma
2011

Surgical sepsis and organ crosstalk: the role of the kidney.
The Journal of surgical research
2011

Robotic telepresence: a helpful adjunct that is viewed favorably by critically ill surgical patients.
American journal of surgery
2011

Postinjury resuscitation with human polymerized hemoglobin prolongs early survival: a post hoc analysis.
The Journal of trauma
2011

Nutrition support for the acute lung injury/adult respiratory distress syndrome patient: a review.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2011

Identification of cardiac dysfunction in sepsis with B-type natriuretic peptide.
Journal of the American College of Surgeons
2011

Evaluation and management of peripheral vascular injury. Part 1. Western Trauma Association/critical decisions in trauma.
The Journal of trauma
2011

Computer protocol facilitates evidence-based care of sepsis in the surgical intensive care unit.
The Journal of trauma
2011

Challenges to effective research in acute trauma resuscitation: consent and endpoints.
Shock (Augusta, Ga.)
2011

Availability of acute care surgeons improves outcomes in patients requiring emergent colon surgery.
American journal of surgery
2011

What's better?
JPEN. Journal of parenteral and enteral nutrition
2010

Trauma.
Current opinion in critical care
2010

Therapeutic distant organ effects of regional hypothermia during mesenteric ischemia-reperfusion injury.
Journal of vascular surgery
2010

Sepsis in general surgery: the 2005-2007 national surgical quality improvement program perspective.
Archives of surgery (Chicago, Ill. : 1960)
2010

Resuscitation beyond the abdominal compartment syndrome.
Current opinion in critical care
2010

Presidential address: imagination trumps knowledge.
American journal of surgery
2010

Poloxamer 188 inhibition of ischemia/reperfusion injury: evidence for a novel anti-adhesive mechanism.
Annals of clinical and laboratory science
2010

Performance of a computerized protocol for trauma shock resuscitation.
World journal of surgery
2010

Intestinal ischemic preconditioning after ischemia/reperfusion injury in rat intestine: profiling global gene expression patterns.
Digestive diseases and sciences
2010

Evaluation of empiric antibiotic use in surgical sepsis.
American journal of surgery
2010

Computerized clinical decision support improves mortality in intra abdominal surgical sepsis.
American journal of surgery
2010

Compilation of recommendations from summit on increasing physician nutrition experts.
JPEN. Journal of parenteral and enteral nutrition
2010

American Association for the Surgery of Trauma Organ Injury Scaling: 50th anniversary review article of the Journal of Trauma.
The Journal of trauma
2010

Western Trauma Association critical decisions in trauma: screening for and treatment of blunt cerebrovascular injuries.
The Journal of trauma
2009

Western Trauma Association critical decisions in trauma: nonoperative management of adult blunt hepatic trauma.
The Journal of trauma
2009

Validation of a screening tool for the early identification of sepsis.
The Journal of trauma
2009

The evolving rationale for early enteral nutrition based on paradigms of multiple organ failure: a personal journey.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2009

The USA Multicenter Prehosptial Hemoglobin-based Oxygen Carrier Resuscitation Trial: scientific rationale, study design, and results.
Critical care clinics
2009

Sepsis in general surgery: a deadly complication.
American journal of surgery
2009

Postinjury multiple organ failure.
Injury
2009

Postinjury abdominal compartment syndrome: are we winning the battle?
World journal of surgery
2009

Monitoring trauma and intensive care unit resuscitation with tissue hemoglobin oxygen saturation.
Critical care (London, England)
2009

Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trial.
Journal of the American College of Surgeons
2009

Early hypothermia in severely injured trauma patients is a significant risk factor for multiple organ dysfunction syndrome but not mortality.
Annals of surgery
2009

Early cytokine production risk stratifies trauma patients for multiple organ failure.
Journal of the American College of Surgeons
2009

Central venous pressure versus pulmonary artery catheter-directed shock resuscitation.
Shock (Augusta, Ga.)
2009

Alpha-melanocyte stimulating hormone in critically injured trauma patients.
The Journal of trauma
2009

A multidisciplinary protocol improves electrolyte replacement and its effectiveness.
American journal of surgery
2009

Western trauma association critical decisions in trauma: management of pelvic fracture with hemodynamic instability.
The Journal of trauma
2008

Western trauma association critical decisions in trauma: foreword.
The Journal of trauma
2008

Western Trauma Association (WTA) critical decisions in trauma: management of adult blunt splenic trauma.
The Journal of trauma
2008

Propofol-related infusion syndrome in intensive care patients.
Pharmacotherapy
2008

Postinjury Primary Abdominal Compartment Syndrome.
European journal of trauma and emergency surgery : official publication of the European Trauma Society
2008

Massive transfusion in trauma patients: tissue hemoglobin oxygen saturation predicts poor outcome.
The Journal of trauma
2008

Is there a role for aggressive use of fresh frozen plasma in massive transfusion of civilian trauma patients?
American journal of surgery
2008

Gastric alkalinization after major trauma.
The Journal of trauma
2008

Effects of poloxamer 188 on human PMN cells.
Surgery
2008

Computerized clinical decision support: a technology to implement and validate evidence based guidelines.
The Journal of trauma
2008

Computerized clinical decision support for traumatic shock resuscitation.
Current opinion in critical care
2008

Tissue oxygen saturation predicts the development of organ dysfunction during traumatic shock resuscitation.
The Journal of trauma
2007

The practice of venous thromboembolism prophylaxis in the major trauma patient.
The Journal of trauma
2007

Secondary abdominal compartment syndrome: a potential threat for all trauma clinicians.
Injury
2007

Measurement of intestinal edema using an impedance analyzer circuit.
The Journal of surgical research
2007

Fresh frozen plasma should be given earlier to patients requiring massive transfusion.
The Journal of trauma
2007

Evidence-based medical information technology: the next generation.
The Journal of trauma
2007

Acute lower extremity compartment syndrome (ALECS) screening protocol in critically ill trauma patients.
The Journal of trauma
2007

The impact of diabetes on outcome in traumatically injured patients: an analysis of the National Trauma Data Bank.
American journal of surgery
2006

Risk factors for hepatic morbidity following nonoperative management: multicenter study.
Archives of surgery (Chicago, Ill. : 1960)
2006

Nutrition support in adult trauma patients.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2006

Management of distal femoral and popliteal arterial injuries: an update.
American journal of surgery
2006

Inflammation and the Host Response to Injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care. III. Guidelines for shock resuscitation.
The Journal of trauma
2006

Hypertonic saline resuscitation prevents hydrostatically induced intestinal edema and ileus.
Critical care medicine
2006

Early predictors of prolonged mechanical ventilation in major torso trauma patients who require resuscitation.
American journal of surgery
2006

Conventional dose hypertonic saline provides optimal gut protection and limits remote organ injury after gut ischemia reperfusion.
The Journal of trauma
2006

A multidisciplinary clinical pathway decreases rib fracture-associated infectious morbidity and mortality in high-risk trauma patients.
American journal of surgery
2006

Unsafe at any age: a retrospective review of all-terrain vehicle injuries in two level I trauma centers from 1995 to 2003.
The Journal of trauma
2005

The two-event construct of postinjury multiple organ failure.
Shock (Augusta, Ga.)
2005

Resuscitation-induced intestinal edema decreases the stiffness and residual stress of the intestine.
Shock (Augusta, Ga.)
2005

Resuscitation-induced gut edema and intestinal dysfunction.
The Journal of trauma
2005

Prehospital physiologic data and lifesaving interventions in trauma patients.
Military medicine
2005

Peroxisome proliferator-activated receptor gamma mediates protection against cyclooxygenase-2-induced gut dysfunction in a rodent model of mesenteric ischemia/reperfusion.
Shock (Augusta, Ga.)
2005

Ketamine inhibits lipopolysacharide (LPS) induced gastric luminal fluid accumulation.
The Journal of surgical research
2005

Ischemic preconditioning protects against gut dysfunction and mucosal injury after ischemia/reperfusion injury.
Shock (Augusta, Ga.)
2005

Intra-abdominal hypertension: not just a surgical critical care curiosity.
Critical care medicine
2005

Immune-enhancing enteral nutrients differentially modulate the early proinflammatory transcription factors mediating gut ischemia/reperfusion.
The Journal of trauma
2005

Hypertonic saline resuscitation after mesenteric ischemia/reperfusion induces ileal apoptosis.
The Journal of trauma
2005

Effects of primary and secondary intra-abdominal hypertension on mesenteric lymph flow: implications for the abdominal compartment syndrome.
Shock (Augusta, Ga.)
2005

Complications of nonoperative management of high-grade blunt hepatic injuries.
The Journal of trauma
2005

The next generation in shock resuscitation.
Lancet (London, England)
2004

The immune-enhancing enteral agents arginine and glutamine differentially modulate gut barrier function following mesenteric ischemia/reperfusion.
The Journal of trauma
2004

Superior mesenteric artery occlusion models shock-induced gut ischemia-reperfusion.
The Journal of surgical research
2004

Preload optimization using "starling curve" generation during shock resuscitation: can it be done?
Shock (Augusta, Ga.)
2004

Practice management guidelines for nutritional support of the trauma patient.
The Journal of trauma
2004

Hypertonic saline prevents inflammation, injury, and impaired intestinal transit after gut ischemia/reperfusion by inducing heme oxygenase 1 enzyme.
The Journal of trauma
2004

Gastric feeding as an extension of an established enteral nutrition protocol.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
2004

Enteral glutamine but not alanine maintains small bowel barrier function after ischemia/reperfusion injury in rats.
Shock (Augusta, Ga.)
2004

Vacuum-assisted wound closure achieves early fascial closure of open abdomens after severe trauma.
The Journal of trauma
2003

Supranormal trauma resuscitation causes more cases of abdominal compartment syndrome.
Archives of surgery (Chicago, Ill. : 1960)
2003

Regional hypothermia reduces mucosal NF-kappaB and PMN priming via gut lymph during canine mesenteric ischemia/reperfusion.
The Journal of surgical research
2003

Patients with impending abdominal compartment syndrome do not respond to early volume loading.
American journal of surgery
2003

Morbidity from rib fractures increases after age 45.
Journal of the American College of Surgeons
2003

Hypothermia protects against gut ischemia/reperfusion-induced impaired intestinal transit by inducing heme oxygenase-1.
The Journal of surgical research
2003

Gut dysfunction and intolerance to enteral nutrition in critically ill patients.
Nestle Nutrition workshop series. Clinical & performance programme
2003

Goal-oriented shock resuscitation for major torso trauma: what are we learning?
Current opinion in critical care
2003

Distal aortic perfusion and cerebrospinal fluid drainage for thoracoabdominal and descending thoracic aortic repair: ten years of organ protection.
Annals of surgery
2003

Both primary and secondary abdominal compartment syndrome can be predicted early and are harbingers of multiple organ failure.
The Journal of trauma
2003

Blunt cardiac injuries that require operative intervention: an unsuspected injury.
The Journal of trauma
2003

Abdominal compartment syndrome: the cause or effect of postinjury multiple organ failure.
Shock (Augusta, Ga.)
2003

Treatment of aspiration in intensive care unit patients.
JPEN. Journal of parenteral and enteral nutrition
2002

The type of sodium-coupled solute modulates small bowel mucosal injury, transport function, and ATP after ischemia/reperfusion injury in rats.
Gastroenterology
2002

Standardized trauma resuscitation: female hearts respond better.
Archives of surgery (Chicago, Ill. : 1960)
2002

Specific intraluminal nutrients alter mucosal blood flow during gut ischemia/reperfusion.
JPEN. Journal of parenteral and enteral nutrition
2002

Secondary abdominal compartment syndrome is an elusive early complication of traumatic shock resuscitation.
American journal of surgery
2002

Postinjury enteral tolerance is reliably achieved by a standardized protocol.
The Journal of surgical research
2002

Normal versus supranormal oxygen delivery goals in shock resuscitation: the response is the same.
The Journal of trauma
2002

Intraischemic hypothermia differentially modulates oxidative stress proteins during mesenteric ischemia/reperfusion.
Surgery
2002

Alpha-melanocyte-stimulating hormone protects against mesenteric ischemia-reperfusion injury.
American journal of physiology. Gastrointestinal and liver physiology
2002

Longitudinal changes in bone density in hyperparathyroidism.
Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
1999

Primary hyperaldosteronism in pregnancy. A case report.
The Journal of reproductive medicine
1996

Research Interests

Dr. Moore is the principal investigator for an NIH-funded P50 center grant for the UF Sepsis and Critical Illness Research Center to study the persistent inflammation, immunosuppression and catabolism syndrome (PICS) following sepsis in surgical intensive care unit patients.

Other research interests include:

Translational efforts related to multiple organ failure
Inflammatory response after trauma
Nutrition and the immune system