Amyotrophic lateral sclerosis (ALS): Research Studies

11 Related Result(s)

1. A Study to Evaluate Efficacy, Safety and Tolerability of a Medication in Patients With Amyotrophic Lateral Sclerosis (ALS)

   The purpose of this study is to investigate a new therapy for the improvement of skeletal muscle function in conditions associated with muscle weakness or...

2. A Study to Assess the Efficacy and Safety of H.P. Acthar® Gel in the Treatment of Subjects With Amyotrophic Lateral Sclerosis

   This is a multicenter, multiple dose study to examine the effect of Acthar on functional decline in adult subjects with amyotrophic lateral sclerosis (ALS). ...

3. Biomarkers of ALS

   Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS

   This study will evaluate whether prolonged oral levosimendan can preserve respiratory function more effectively than placebo, resulting in better patient...

4. Use of Dalfampridin in Primary Lateral Sclerosis

   This study will comprise an 18-week open label safety and tolerability trial. In this study, a total of 35 subjects with primary lateral sclerosis PLS or...

5. Lung Volume Recruitment Combined With Expiratory Muscle Strength Training in ALS

   The purpose of this study is to investigate the effects of two treatment techniques called Expiratory Muscle Strength Training (EMST) and Lung Volume...

6. Natural History of ALS and Other Motor Neuron Disorders

   ALS is a devastating degenerative disorder which leads to progressive disability and death in an average of four years. The cause is unknown and there is no...

7. Acute Adenosine 2A Receptor Antagonism to Promote Breathing Plasticity in ALS

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8. Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease (AIH in ALS)

   Participants will complete a single, 45 minute session of acute intermittent hypoxia (low oxygen air) and a single, 45 minute session of sham acute...

9. Delineating Physiologic Mechanisms of Swallowing Impairment and Decline in ALS

   Individuals with Amyotrophic Lateral Sclerosis are at high risk for swallowing impairment (dysphagia) which leads to malnutrition, decreased pulmonary health...

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