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Toxoplasmosis

Definition

Toxoplasmosis is an infection due to the parasite Toxoplasma gondii.

Causes

Toxoplasmosis is found in humans worldwide and in many kinds of animals and birds. The parasite also lives in cats.

Human infection may result from:

  • Blood transfusions or solid organ transplants
  • Handling cat litter
  • Eating contaminated soil
  • Eating raw or undercooked meat (lamb, pork, and beef)

Toxoplasmosis also affects people who have weakened immune systems. These people are more likely to have symptoms.

The infection may also be passed from an infected mother to her baby through the placenta. This results in congenital toxoplasmosis.

Symptoms

There may be no symptoms. If there are symptoms, they usually occur about 1 to 2 weeks after contact with the parasite. The disease can affect the brain, lung, heart, eyes, or liver.

Symptoms in people with otherwise healthy immune systems can include:

Symptoms in people with a weakened immune system can include:

Exams and Tests

The health care provider will perform a physical exam. Tests that may be done include:

Treatment

People without symptoms usually do not need treatment.

Medicines to treat the infection include an antimalarial drug and antibiotics. People with AIDS should continue treatment for as long as their immune system is weak, to prevent the disease from reactivating.

Outlook (Prognosis)

With treatment, people with a healthy immune system usually recover well.

Possible Complications

The disease may return.

In people with a weakened immune system, the infection may spread throughout the body, leading to death.

When to Contact a Medical Professional

Contact your provider for an appointment if you develop symptoms of toxoplasmosis. Medical care is needed right away if symptoms occur in:

  • Infants or babies
  • Someone with a weakened immune system due to certain medicines or disease

Also seek medical treatment right away if the following symptoms occur:

  • Confusion
  • Seizures

Prevention

Tips for preventing this condition:

  • Do not eat undercooked meat.
  • Wash hands after handling raw meat.
  • Keep children's play areas free from cat and dog feces.
  • Wash your hands thoroughly after touching soil that may be contaminated with animal feces.

Pregnant women and those with weakened immune systems should take the following precautions:

  • Do not clean cat litter boxes.
  • Do not touch anything that may contain cat feces.
  • Do not touch anything that could be contaminated by insects, such as cockroaches and flies that may be exposed to cat feces.

Pregnant women and those with HIV/AIDS should be screened for toxoplasmosis. A blood test can be done.

In some cases, medicine to prevent toxoplasmosis may be given.

Gallery

Eye
The eye is the organ of sight, a nearly spherical hollow globe filled with fluids (humors). The outer layer or tunic (sclera, or white, and cornea) is fibrous and protective. The middle layer (choroid, ciliary body and the iris) is vascular. The innermost layer (the retina) is nervous or sensory. The fluids in the eye are divided by the lens into the vitreous humor (behind the lens) and the aqueous humor (in front of the lens). The lens itself is flexible and suspended by ligaments which allow it to change shape to focus light on the retina, which is composed of sensory neurons.
Congenital toxoplasmosis
Human infection with the toxoplasma gondii protozoan results from ingesting contaminated raw meat or soil, or careless handling of the contents of an infected cat's litter box. An infected pregnant woman can transmit the infection to her fetus (congenital toxoplasmosis).

References

Mcleod R, Boyer KM. Toxoplasmosis (Toxoplasma gondii). In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 316.

Montoya JG, Boothroyd JC, Kovacs JA. Toxoplasma gondii. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 278.

Last reviewed November 23, 2021 by Jatin M. Vyas, MD, PhD, Associate Professor in Medicine, Harvard Medical School; Associate in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team..

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