NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol

Purpose

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists that has been shown to prolong survival.

Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic changes or abnormalities (mutations) may benefit more from treatment which targets their tumor's particular genetic mutation, and may help doctors plan better treatment for patients with solid tumors or non-Hodgkin lymphomas.

Study details

Patients undergo biopsy along with tumor mutational screening of the biopsy material for specific, pre-defined mutations, amplifications, or translocations of interest via tumor sequencing and immunohistochemistry. Patients also undergo collection of blood samples for research purposes.

Conditions

  • Brain and Nervous System
  • Lymphoma - Non-Hodgkin
  • Pediatric (Childhood) Cancer
  • Sarcoma

Contact

The study team can discuss eligibility criteria with you as well as any additional questions you may have:

Age

18 and under
18 to 65

Gender

Male
Female

Keywords

Ensartinib, Erdafitinib, Targeted therapy, Genetic testing

Principal Investigator

William " Slayton, M.D.

Sponsoring Group

Department of Pediatrics

Department

MD-PEDS-HEMATOLOGY

Contact Information

trials@cancer.ufl.edu

(352) 273-8675


Be an Informed Participant

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Know Who to Contact

  • Eligibility: For questions about a specific study and who is eligible to participate, call or email the contact person listed for that study.
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