(PROGRESS) A Phase I and Open Label, Randomized, Controlled Phase II Study Testing the Safety, Toxicities, and Efficacy of MK-3475 in Combination With MRI-guided Laser Ablation in Recurrent Malignant Gliomas

Purpose

The blood brain barrier (BBB) is a major obstacle to drug delivery in the treatment of malignant brain tumors including Glioblastoma multiforme (GBM). MRI-guided laser ablation (MLA) has been noted to disrupt peritumoral BBB, which could then lead to increased access of new tumor antigens to the lymphovascular system and vice versa of immune effector cells to the tumor for effective activation of the immune system.

Therefore the combination of MK-3475 and MLA as proposed in this protocol is hypothesized to create a therapeutic synergy in which MLA increases material access to promote immune activation and then MK-3475 maximizes these tumor-specific immune reactions to impart effective tumor control.

Eligibility

  • 18 years old and older 
  • Disease: Brain tumor
  • Disease type: Recurrent Glioblastoma Multiforme (GBM)

For additional information about eligibility criteria, please contact the study coordinator Annie Allen: 

Age

18 to 65
65 and over

Gender

Male
Female

Can be done from home

No

Keywords

Brain Tumors, Glioblastoma multiforme, Metastatic brain tumor, Glioma, Brain Tumor

Principal Investigator

David D Tran, M.D.

Department

MD-NEUROLOGICAL SURGERY

Contact Information

anne.allen@neurosurgery.ufl.edu

(352) 294-8836


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