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Impact of Nuedexta on Bulbar Physiology and Function in ALS

Purpose

The purpose of this research is to determine if Nuedexta, an FDA approved and routinely prescribed medication, improves speech and swallowing functions in people with ALS.

Procedures

If you agree to participate, you will be asked to attend 2 evaluations 30-days apart and undergo a swallowing x-ray study, cough testing, speech testing, and a tongue pressure exam.

Eligibility

  • 18-90 years old
  • Diagnosis of probable-definite ALS (El-Escorial Criterion); ALSFRS-R Bulbar subscale score <10
  • Bamboo oral reading speaking rate <140 words per minute
  • No allergies to barium sulfate

For additional study information, please contact Kelby Magennis:

Age

18 to 65
65 and over

Gender

Male
Female

Monetary compensation

No

Can be done from home

No

Keywords

ALS, ALS - resources, Amyotrophic lateral sclerosis, Neurology

Principal Investigator

Emily K. Plowman, PhD, CCC-SLP

Department

Neurology

Contact Information

kmagennis@phhp.ufl.edu

352-273-8632

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Studies listed on this site have been approved by a UF Institutional Review Board (IRB), which works to ensure the welfare and rights of research participants as required by federal regulations. Study listings are provided by the UF Clinical and Translational Science Institute in collaboration with UF research teams and the UF IRBs.

Be an Informed Participant

Before deciding to participate in a research study, take time to learn about clinical research, how it's conducted and your rights as a research participant. Following are some helpful resources from independent sources. Always remember that a clinical research study is research, not treatment.

Know Who to Contact

  • Eligibility: For questions about a specific study and who is eligible to participate, call or email the contact person listed for that study.
  • Your Rights: For questions about your rights as a research participant, contact the UF Institutional Review Boards at 352-273-9600.
  • Feedback: For general questions or feedback about study listings, email the UF Clinical and Translational Science Institute at UFStudies@health.ufl.edu.

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