- Pediatric Asthma Booklet
- Dr. Mutasim Abu Hasan on Asthma
Pharmacogenomic-Based Treatment of Ambulatory Asthma
Inhaled corticosteroids (ICS) are the most effective treatment of persistent asthma in children6 but there is variability in response that may have a genetic basis. Montelukast, a leukotriene receptor antagonist, is an alternative controller medication. Also, there is some evidence that genetic variation in leukotriene pathway candidate genes or transporter proteins contribute to variability in response.
It is our hypothesis that selection of pharmacotherapy based on genetic variations will decrease exacerbations and cost to treat asthma in children. We will test this hypothesis through the following aims:
- Collect salivary samples from all new patients evaluated in the Pediatric Pulmonary Clinic, isolate DNA and store in the Center for Pharmacogenomics;
- Prospectively collect data on asthma exacerbations (ED visit, hospitalization or short course of oral steroids) and costs;
- Genotype samples for selected genetic polymorphisms and test for associations with exacerbations; and
- Conduct a randomized controlled trial comparing pharmacotherapy selected by NIH guidelines v genetic based stratification.
We anticipate seeking funding from UF CTSI for aims 1 and 3 and submitting an RO1 for aim 4 once there is sufficient pilot data.
Adherence to NIH/EPR3 Guidelines for ED and Hospital Treatment
There is variability in adherence to NIH Guidelines for the treatment of acute asthma in our ED and in-patient service. It is our hypothesis that improving adherence will decrease admissions from the ED and shorten length of stay of those requiring admission. Our aims are: 1) collect data on adherence to the guidelines for 3 months; 2) provide education and clinical pathways based on guidelines to ED physicians, hospitalists, and respiratory therapists/ nurses; and (3) measure adherence and determine the extent of reductions in hospital admissions and hospital length of stay.
Links and Resources
- Allergy and Asthma Network, Mothers of Asthmatics
- American Academy of Allergy Asthma and Immunology
- National Heart, Lung, and Blood Institute Health Information Center
- American Lung Association [cited 2012 Jun 29]
- American Thoracic Society - PULMONARY : CRITICAL CARE :: SLEEP [cited 2012 Jun 29]
- Asthma - PubMed Health [Internet]
- Asthma and Allergy Foundation of America - Information About Asthma, Allergies, Food Allergies and More! [cited 2012 Jun 29]
- Asthma Home | Indoor Air | US Environmental Protection Agency [cited 2012 Jun 29]
- Asthma in Children: MedlinePlus [cited 2012 Jun 29]
- CDC - Asthma [cited 2012 Jun 29]
- CDC - Asthma - Adolescent and School Health [cited 2012 Jun 29]
- FDA: Children and Asthma: The Goal Is Control [cited 2012 Jun 29]
- Florida Asthma Coalition [cited 2012 Jun 29]
- What Is Asthma? - NHLBI, NIH [cited 2012 Jun 29]
Conditions & Services
- Allergic rhinitis
- Allergies - overview
- Asthma and allergy resources
- Asthma in children
- Chronic cough
- Drug allergies
- Exercise-Induced Symptoms and Pseudoasthma Syndromes
- Food allergy
- Insect bites and stings
- Latex Allergy
- Pulmonary Diseases Related to Hypersensitivity
- Skin allergy
- Vocal Cord Dysfunction
Shands hospitals and UF Physician practices accept insurance from numerous providers, including Aetna, Blue Cross Blue Shield of Florida, CIGNA, Humana, Capital Health, United Healthcare, Medicaid, and state and government services. For a full list of accepted plans visit our Insurance / Billing page.
Insurance acceptance varies between physicians and locations and is subject to change. To confirm that a specific physician will accept your insurance, please contact the practice using the telephone numbers listed at the top of the page. A representative will be happy to assist you.