Nicole M Iovine, MD, PhD

(352) 294-5480

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Publications

Dissemination mechanisms of NDM genes in hospitalized patients.
JAC-antimicrobial resistance
2021

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19.
The New England journal of medicine
2021

The Clinical Presentation and Immunology of Viral Pneumonia and Implications for Management of Coronavirus Disease 2019.
Critical care explorations
2020

Recovery of Curvularia mold from a duodenoscope after reprocessing in accordance with the manufacturer's cleaning protocol.
American journal of infection control
2020

Optimizing COVID-19 testing capabilities and clinical management using pathology informatics.
JAMIA open
2020

Evaluation of patient risk factors for infection with carbapenem-resistant Enterobacteriaceae.
American journal of infection control
2020

Infectious Diseases Physicians: Leading the Way in Antimicrobial Stewardship.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2018

IKBKG (NEMO) 5' Untranslated Splice Mutations Lead to Severe, Chronic Disseminated Mycobacterial Infections.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2018

Complete Genome Sequence of Dengue virus Type 2 from a Resident of North-Central Florida with Locally Transmitted Dengue Fever.
Genome announcements
2017

Zika and Chikungunya virus co-infection in a traveller returning from Colombia, 2016: virus isolation and genetic analysis.
JMM case reports
2016

Hemagglutinin Gene Clade 3C.2a Influenza A(H3N2) Viruses, Alachua County, Florida, USA, 2014-15.
Emerging infectious diseases
2016

Severity of influenza A(H1N1) illness and emergence of D225G variant, 2013-14 influenza season, Florida, USA.
Emerging infectious diseases
2015

Effects of Klebsiella pneumoniae carbapenemase subtypes, extended-spectrum β-lactamases, and porin mutations on the in vitro activity of ceftazidime-avibactam against carbapenem-resistant K. pneumoniae.
Antimicrobial agents and chemotherapy
2015

An outbreak of acute delirium from exposure to the synthetic cannabinoid AB-CHMINACA.
Clinical toxicology (Philadelphia, Pa.)
2015

High Percentage of False-Positive Results for Influenza B Obtained With a Rapid Influenza Point-Of-Care Test
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2014

Enteric bacteria promote human and mouse norovirus infection of B cells.
Science (New York, N.Y.)
2014

Detection of Neisseria meningitidis from negative blood cultures and cerebrospinal fluid with the FilmArray blood culture identification panel.
Journal of clinical microbiology
2014

Carbapenem-resistant Klebsiella pneumoniae strains exhibit diversity in aminoglycoside-modifying enzymes, which exert differing effects on plazomicin and other agents.
Antimicrobial agents and chemotherapy
2014

Resistance mechanisms in Campylobacter jejuni.
Virulence
2013

Multi-functional analysis of Klebsiella pneumoniae fimbrial types in adherence and biofilm formation.
Virulence
2013

Log reduction of multidrug-resistant Gram-negative bacteria by the neutrophil-derived recombinant bactericidal/permeability-increasing protein.
International journal of antimicrobial agents
2013

Antibacterial analysis of surgical adhesives.
Plastic and reconstructive surgery
2012

Campylobacter capsule and lipooligosaccharide confer resistance to serum and cationic antimicrobials.
Virulence
2011

Reactive nitrogen species contribute to innate host defense against Campylobacter jejuni.
Infection and immunity
2008

A paradigm for direct stress-induced mutation in prokaryotes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2006

Antimicrobial resistance in Campylobacter.
Emerging infectious diseases
2004

Antibiotics in animal feed and spread of resistant Campylobacter from poultry to humans.
Emerging infectious diseases
2004

The carboxyl-terminal domain of closely related endotoxin-binding proteins determines the target of protein-lipopolysaccharide complexes.
The Journal of biological chemistry
2002

Lipopolysaccharide (LPS)-binding proteins BPI and LBP form different types of complexes with LPS.
The Journal of biological chemistry
1997

An opsonic function of the neutrophil bactericidal/permeability-increasing protein depends on both its N- and C-terminal domains.
Proceedings of the National Academy of Sciences of the United States of America
1997

Research Interests

I am trained as both an Infectious Disease specialist and as an expert in innate defense against bacterial infection, with a focus on Gram-negative organisms. As an Infectious Disease specialist, I am particularly interested in treatment approaches to multidrug-resistant Gram-negative infections. As a researcher, I study the innate defenses against these types of infections. In one project, I study the Bactericidal/Permeability-Increasing protein (BPI) - an endogenous antibiotic found in neutrophils and available in recombinant form. BPI has potent activity against Gram-negative bacteria, including multidrug-resistant clinical isolates I collect.

I have a 3-year grant from the Bankhead-Coley Research Council entitled "The Role of Smoking in the Promotion of Crohn's Disease: A Predisposing Factor to Colon Cancer." The study population consists of Crohn's Disease patients who are seen in the GI clinic at UF and who have been genotyped for the major Crohn's Disease polymorphisms as part of a separate study. In the first part of my study, I am performing chart reviews of these patients to score their disease severity. This scoring system includes smoking status and the data are analyzed based on that variable as well as their genotypes. In the second part of the study, monocyte-derived macrophages from these patients will be assessed for their ability to kill enteric bacteria and elicit pro- and anti-inflammatory cytokines.

I have expertise in the area of Campylobacter jejuni pathogenesis, and study the role of innate immune mechanisms including reactive nitrogen species, BPI and most recently, autophagy in host defense against C. jejuni infection.