UF Health allergist says no reason past allergies should dissuade people from COVID-19 vaccination

Lyda Cuervo Pardo, M.D.Getting a vaccination against COVID-19 makes sense for just about everybody. Vaccines remain highly effective in preventing infection, severe disease and hospitalization. Unvaccinated Americans are 11 times more likely to die of COVID-19 than those who have received the shots, according to the U.S. Centers for Disease Control and Prevention.

Having a history of allergic reactions, experts say, is rarely a reason to avoid getting vaccinated.

Lyda Cuervo Pardo, M.D., a University of Florida Health allergist and immunologist and an assistant professor in the UF College of Medicine’s division of rheumatology and clinical immunology, talks about why allergies should not stand in the way of getting vaccinated.

Question: Does an allergic reaction to anything in my past mean it wouldn’t be safe to get a COVID-19 vaccination?

Answer: No, not at all. People with a history of an allergic reaction to a medication, a food, an environmental allergen such as pollen, trees, weeds, dust mites, even those with a history of an allergic reaction to latex or venoms like a bee sting, are very unlikely to have an allergic reaction to one of the COVID-19 vaccines. Patients with a history of an allergic reaction, even a severe reaction, should not be concerned about getting vaccinated.

People should remember the COVID vaccines do not contain eggs, gelatins, preservatives or latex, some of the things people often worry about when it comes to allergies.

If there’s ever a concern about your candidacy to receive a COVID-19 vaccine, the best advice is to see a board-certified allergist and immunologist so they can determine if it’s safe for you.

Q: Might someone have a reaction to one of the ingredients in the vaccines?

A: In very rare cases, someone might be allergic to an ingredient in the Pfizer and Moderna vaccines called polyethylene glycol. This same ingredient is found in many common medications. It’s in MiraLAX, for example, a medication commonly used to treat constipation.

The Johnson & Johnson vaccine doesn’t contain polyethylene glycol. But it has an ingredient known as polysorbate. Again, cases of an allergic reaction to this are very rare.

If you have a known allergy to these or other ingredients of any vaccine, you should consult with your doctor before getting vaccinated. If indicated, you might be referred to an allergist-immunologist. They can help you determine if you are still a candidate for a vaccination even with your history.

If you are allergic to polyethylene glycol, you might not be able to receive an mRNA vaccine — the Pfizer and Moderna vaccines. But you should discuss with your doctor if instead you would be a candidate for the Johnson & Johnson vaccination.

If you have a known allergy to polysorbate in the Johnson & Johnson vaccine, ask your doctor if you can get an an mRNA vaccine.   

Q: How rare is it for someone to have a serious allergic reaction to a COVID-19 vaccination?

A: It is very rare. Tens of millions of Americans have now safely received COVID-19 vaccinations, and reports of serious allergic reactions are extraordinarily uncommon. Serious reactions to the vaccines have been reported, on average, at about 4.7 for every million doses of the Pfizer vaccine administered. In the case of Moderna, it’s 2.5 cases of reaction, also known as anaphylaxis, per million doses.

In general, most of the reactions patients experience are minor local symptoms, such as pain at the injection site — essentially a sore arm — a rash, inflammation of the lymph nodes. Most of the symptoms people experience are extremely mild.

Most of these develop in the first three days after vaccination. And they resolve just as quickly, usually within one to three days.

It is important to note that any location administering vaccinations is well-equipped to deal with an allergic reaction. Medical professionals are on hand, and all patients are monitored for at least 15 minutes after getting their shot. Anyone with a history of a reaction to other types of vaccines are still eligible for a vaccination. But they are monitored for 30 minutes as a precaution.

Q: What are your patients most concerned about when it comes to the coronavirus?

A: A lot of patients who come to me worry that their normal allergy symptoms, like their seasonal allergies, might be perceived by those around them as signs that they have COVID-19. Or the patients might be worried themselves that these sort of minor allergy symptoms might be COVID-19. And they are correct: Sometimes it can be difficult to establish the difference when you’re just having regular congestion or a runny nose from allergies.

I tell people to watch for more serious symptoms, such as fever, headaches — symptoms that are normally not present with allergies. They should, of course, be concerned if there is a lack of improvement even after they take their regular allergy medications. That’s when they should be thinking about getting tested for the coronavirus.

Q: What would you say to people with a history of allergies if they’re worried about getting a COVID-19 vaccination?

A: As an allergist, I can confidently say that the vaccines save lives. I encourage all my patients with a history of allergic reactions to foods, medications, latex, the environment, to not be concerned about potential increased risk for having a reaction to the COVID-19 vaccines. The vaccines are incredibly safe. We have seen, through all of 2021, millions and millions of people getting vaccinated without any problems at all, with just mild reactions in almost all the cases where a reaction is observed at all. The consequences of being unvaccinated and getting COVID-19 are far, far more dangerous than any of the minor side effects of vaccination. 

Media contact: Ken Garcia at kdgarcia@ufl.edu or 352-265-9408.


Learn more about UF Health's efforts to combat the COVID-19 pandemic at Coronavirus.UFHealth.org.

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Bill Levesque

Science Writer

Bill Levesque joined the UF Health staff in May 2017 as a science writer covering the Institute on Aging and research of faculty physicians in the College of Medicine. He...Read More