James Wynne, M.D.

James W Wynne, M.D.

(352) 273-8740

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Pilchard orthomyxovirus (POMV). I. Characterisation of an emerging virus isolated from pilchards Sardinops sagax and Atlantic salmon Salmo salar.
Diseases of aquatic organisms

Stop Being So Sensitive: An Exceptionally Rare Report of Ustekinumab-Induced Sub-acute Hypersensitivity Pneumonitis.
Turkish journal of anaesthesiology and reanimation

Exposure Risk for Infection and Lack of Human-to-Human Transmission of Mycobacterium ulcerans Disease, Australia.
Emerging infectious diseases

Benign but Not Harmless: Solitary Fibrous Tumor.
The American journal of medicine

Proteomics informed by transcriptomics reveals Hendra virus sensitizes bat cells to TRAIL-mediated apoptosis.
Genome biology

Comparative analysis of bat genomes provides insight into the evolution of flight and immunity.
Science (New York, N.Y.)

Transcriptome analyses of amoebic gill disease-affected Atlantic salmon (Salmo salar) tissues reveal localized host gene suppression.
Marine biotechnology (New York, N.Y.)

Resistance to amoebic gill disease (AGD) is characterised by the transcriptional dysregulation of immune and cell cycle pathways.
Developmental and comparative immunology

Major histocompatibility polymorphism associated with resistance towards amoebic gill disease in Atlantic salmon (Salmo salar L.).
Fish & shellfish immunology

Menopause, medroxyprogesterone and breathing during sleep.
The American journal of medicine

Alcohol increases sleep apnea and oxygen desaturation in asymptomatic men.
The American journal of medicine

Sleep-disordered breathing and nocturnal oxygen desaturation in postmenopausal women.
The American journal of medicine

Disordered breathing and oxygen desaturation during sleep in patients with chronic obstructive lung disease (COLD).
The American journal of medicine

Research Interests

Dr. Wynn's clinical expertise and research program centers on the investigation of sepsis (life-threatening infection or "blood poisoning") in newborn and premature infants. Sepsis can affect 6/10 immature preterm neonates and 4/10 of those infected suffer death/major disability even in developed countries. Applications of his work include improving the accuracy of sepsis diagnostic methods, identification of prognostic and clinical stratification markers, and discovery of potential opportunities for translational interventions aimed at improving infection-related outcomes.