Frederic Kaye, M.D.

Frederic J Kaye, M.D.

(352) 265-0725

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Publications

Delta-like Protein 3 Expression and Targeting in Merkel Cell Carcinoma
Oncologist
2020

Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival
The Journal Of Clinical Investigation
2019

MYB-activated models for testing therapeutic agents in adenoid cystic carcinoma
Oral oncology
2019

Co-occurring alterations in the RAS-MAPK pathway limit response to MET inhibitor treatment in MET exon 14 skipping mutation-positive lung cancer
Clinical Cancer Research
2019

Adaptive Transcriptional Responses by CRTC Coactivators in Cancer
Trends In Cancer
2019

The Prevalence of Rhesus-Negative Blood Group Among Patient With Small Cell Lung Cancer and Analysis of Its Effect on Overall Survival
Frontiers in Oncology
2018

Stereotactic Ablative Body Radiotherapy for Primary Non-Small-Cell Lung Cancer: Achieving Local Control with a Lower Biologically Effective Dose.
Cancer Investigation
2018

Role of INSL4 Signaling in Sustaining the Growth and Viability of LKB1-Inactivated Lung Cancer
Journal of the National Cancer Institute
2018

CRTC1-MAML2 fusion-induced lncRNA LINC00473 expression maintains the growth and survival of human mucoepidermoid carcinoma cells
Oncogene
2018

CDK4/6 inhibition stabilizes disease in patients with p16-null non-small cell lung cancer and is synergistic with mTOR inhibition
Oncotarget
2018

Significantly mutated genes and regulatory pathways in SCLC-a meta-analysis
Cancer Genetics
2017

Phase 1/2 Study of the Cd56-Targeting Antibody-Drug Conjugate Lorvotuzumab Mertansine (Imgn901) in Combination With Carboplatin/Etoposide in Small-Cell Lung Cancer Patients With Extensive-Stage Disease
Clinical Lung Cancer
2017

Treatment of Ameloblastoma and Ameloblastic Carcinoma With Radiotherapy
European Archives of Oto-Rhino-Laryngology
2016

Silencing Receptor Epha2 Enhanced Sensitivity to Lipoplatin (Tm) in Lung Tumor and Mpm Cells
Cancer Investigation
2016

A Sensitive Nanostring-Based Assay to Score Stk11 (Lkb1) Pathway Disruption in Lung Adenocarcinoma
Journal of Thoracic Oncology
2016

Targeting Focal Adhesion Kinase and Resistance to Mtor Inhibition in Pancreatic Neuroendocrine Tumors
Journal of the National Cancer Institute
2015

Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer
Journal of the National Cancer Institute
2015

Re: a Cancer Theory Kerfuffle Can Lead To New Lines of Research
Journal of the National Cancer Institute
2015

Cisplatin Loaded Albumin Mesospheres for Lung Cancer Treatment
American Journal of Cancer Research
2015

Deregulated Ts Promotes Tumor Progression in Diverse Hematopoietic and Mesenchymal Cell Lineages
Cancer Research
2014

Crtc1/Maml2 Gain-Of-Function Interactions With Myc Create a Gene Signature Predictive of Cancers With Creb-Myc Involvement
Proceedings of the National Academy of Sciences
2014

Analysis of 320 Gastroenteropancreatic Neuroendocrine Tumors Identifies Ts Expression as Independent Biomarker for Survival
International Journal of Cancer
2014

A Unifying Gene Signature for Adenoid Cystic Cancer Identifies Parallel Myb-Dependent and Myb-Independent Therapeutic Targets
Oncotarget
2014

The 3Rd Salivary Gland Tumor Workshop Meeting Report
Head & neck
2013

Integrated High-Resolution Array Cgh and Sky Analysis of Homozygous Deletions and Other Genomic Alterations Present in Malignant Mesothelioma Cell Lines
Cancer Genetics
2013

Directed Evolution of Aav Capsid for Targeted Cancer Therapy
Molecular Therapy
2013

Characterization of Tumorigenic Cell Lines From the Recurrence and Lymph Node Metastasis of a Human Salivary Mucoepidermoid Carcinoma
Oral oncology
2013

Ephrin-A1 Inhibits Nsclc Tumor Growth Via Induction of Cdx-2 a Tumor Suppressor Gene
Bmc Cancer
2012

Dna Methyltransferase Inhibitor, Zebularine, Delays Tumor Growth and Induces Apoptosis in a Genetically Engineered Mouse Model of Breast Cancer
Molecular Cancer Therapeutics
2012

Altered Lkb1/Creb-Regulated Transcription Co-Activator (Crtc) Signaling Axis Promotes Esophageal Cancer Cell Migration and Invasion
Oncogene
2012

Successful Erlotinib Rechallenge After Erlotinib-Induced Interstitial Lung Disease
Journal of Thoracic Oncology
2011

Novel Ampk/ Crtc Signaling Pathway in Metabolism and Lung Cancer
International Journal of Molecular Medicine
2011

Erlotinib Or Gefitinib for Non-Small-Cell Lung Cancer
New England Journal of Medicine
2011

Crtc1 Expression During Normal and Abnormal Salivary Gland Development Supports a Precursor Cell Origin for Mucoepidermoid Cancer
Gene Expression Patterns
2011

Lkb1 Regulates a Novel Crtc1: Creb: Nr4A2 Pathway in Lung Cancer
Journal of Thoracic Oncology
2010

Enhanced Growth Inhibition By Combined Dna Methylation/Hdac Inhibitors in Lung Tumor Cells With Silenced Cdkn2a
International Journal of Oncology
2010

Enhanced Activity of the Creb Co-Activator Crtc1 in Lkb1 Null Lung Cancer
Oncogene
2010

Research Interests

  • Molecular basis for human cancer and the clinical management of patients with thoracic malignancies.

Active Research Studies