Aparna Wagle Shukla, M.D.

Aparna A Wagle Shukla, M.D.

(352) 294-5400

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Publications

Therapeutic Advances in the Treatment of Holmes Tremor: Systematic Review
Neuromodulation
2020

Secondary Worsening Following DYT1 Dystonia Deep Brain Stimulation: A Multi-country Cohort.
Frontiers in human neuroscience
2020

Reply to letter to the editor, "A randomized study of botulinum toxin versus botulinum toxin plus physical therapy for treatment of cervical dystonia."
Parkinsonism & related disorders
2020

Quantitative Separation of Tremor and Ataxia in Essential Tremor.
Annals of neurology
2020

Potential role for rTMS in treating Primary Orthostatic Tremor.
Brain stimulation
2020

Longitudinal follow-up with VIM thalamic deep brain stimulation for dystonic or essential tremor.
Neurology
2020

Imaging of dopamine transporters in Parkinson disease: a meta-analysis of 18 F/123 I-FP-CIT studies.
Annals of clinical and translational neurology
2020

High-dose Botulinum Toxin Therapy: Safety, Benefit, and Endurance of Efficacy.
Tremor and other hyperkinetic movements (New York, N.Y.)
2020

Gait characterization for patients with orthostatic tremor.
Parkinsonism & related disorders
2020

Effects of ventral intermediate nucleus deep brain stimulation across multiple effectors in essential tremor.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2020

Dystonia & tremor: A cross-sectional study of the dystonia coalition cohort
Neurology
2020

Dysarthria and Speech Intelligibility Following Parkinson's Disease Globus Pallidus Internus Deep Brain Stimulation
Journal of Parkinson's disease (Online)
2020

Development and Validation of the Orthostatic Tremor Severity and Disability Scale (OT-10)
Movement Disorders
2020

Deep Brain Stimulation in Essential Tremor: Targets, Technology, and a Comprehensive Review of Clinical Outcomes
Expert Review of Neurotherapeutics
2020

Cortical Oscillations in Cervical Dystonia and Dystonic Tremor.
Cerebral cortex communications
2020

Clinical and imaging features of newly recognized Kelch-like protein 11 paraneoplastic syndrome.
Neurology
2020

Chloroquine and hydroxychloroquine in the context of COVID-19.
Drugs in context
2020

An International Survey of Deep Brain Stimulation Utilization in Asia and Oceania: The DBS Think Tank East.
Frontiers in human neuroscience
2020

A pooled meta-analysis of GPi and STN deep brain stimulation outcomes for cervical dystonia.
Journal of neurology
2020

Square Biphasic Pulse Deep Brain Stimulation for Parkinson's Disease: The BiP-PD Study.
Frontiers in human neuroscience
2019

Sniffing out cognitive decline in patients with or without evidence of dopaminergic deficit
Clinical Parkinsonism & Related Disorders
2019

STN vs. GPi deep brain stimulation for tremor suppression in Parkinson disease: A systematic review and meta-analysis.
Parkinsonism & related disorders
2019

Reply: Thalamotomy for tremor normalizes aberrant pre-therapeutic visual cortex functional connectivity.
Brain : a journal of neurology
2019

Network-level connectivity is a critical feature distinguishing dystonic tremor and essential tremor.
Brain : a journal of neurology
2019

Importance of the initial response to GPi deep brain stimulation in dystonia: A nine year quality of life study.
Parkinsonism & related disorders
2019

Gait worsening and the microlesion effect following deep brain stimulation for essential tremor.
Journal of neurology, neurosurgery, and psychiatry
2019

Expanding horizons for clinical applications of chloroquine, hydroxychloroquine, and related structural analogues.
Drugs in context
2019

Essential requisites for rest tremor assessment in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society
2019

Cortical dynamics within and between parietal and motor cortex in essential tremor.
Movement disorders : official journal of the Movement Disorder Society
2019

A randomized study of botulinum toxin versus botulinum toxin plus physical therapy for treatment of cervical dystonia.
Parkinsonism & related disorders
2019

Ventral Intermediate Nucleus Versus Zona Incerta Region Deep Brain Stimulation in Essential Tremor.
Movement disorders clinical practice
2018

Th17 lymphocyte spearheads the immune attack in Parkinson's disease: New evidence for neuronal death.
Movement disorders : official journal of the Movement Disorder Society
2018

Square biphasic pulse deep brain stimulation for essential tremor: The BiP tremor study.
Parkinsonism & related disorders
2018

Reply: Visually-sensitive networks in essential tremor: evidence from structural and functional imaging.
Brain : a journal of neurology
2018

Rationale and patient selection for interventional therapies in Parkinson's disease.
Expert review of neurotherapeutics
2018

Physiological effects of subthalamic nucleus deep brain stimulation surgery in cervical dystonia.
Journal of neurology, neurosurgery, and psychiatry
2018

Microlesion effects, suboptimal lead placement and disease progression are critical determinants for DBS tolerance in essential tremor.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2018

Is deep brain stimulation therapy underutilized for movement disorders?
Expert review of neurotherapeutics
2018

Globus pallidus internus deep brain stimulation induces tremor in Parkinson's disease: A paradoxical phenomenon.
Journal of the neurological sciences
2018

Globus Pallidum DBS for Task-Specific Dystonia in a Professional Golfer.
Tremor and other hyperkinetic movements (New York, N.Y.)
2018

Deep Brain Stimulation in Parkinson's Disease.
Parkinson's disease
2018

Deep Brain Stimulation at Variable Frequency to Improve Motor Outcomes in Parkinson's Disease.
Movement disorders clinical practice
2018

Combined effects of rTMS and botulinum toxin therapy in benign essential blepharospasm.
Brain stimulation
2018

A widespread visually-sensitive functional network relates to symptoms in essential tremor.
Brain : a journal of neurology
2018

Virtual visits for Parkinson disease: A multicenter noncontrolled cohort.
Neurology. Clinical practice
2017

Variable frequency stimulation of subthalamic nucleus in Parkinson's disease: Rationale and hypothesis.
Parkinsonism & related disorders
2017

The ice test to differentiate essential tremor from Parkinson's disease tremor.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2017

Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry.
Movement disorders : official journal of the Movement Disorder Society
2017

Functional activity of the sensorimotor cortex and cerebellum relates to cervical dystonia symptoms.
Human brain mapping
2017

Focal cervical dystonia presents in the setting of acute cerebellar hemorrhage.
Journal of the neurological sciences
2017

Extended-Release Amantadine-A Smart Pill for Treatment of Levodopa-Induced Dyskinesia but Does the Evidence Justify the Cost?
JAMA neurology
2017

DBS Programming: An Evolving Approach for Patients with Parkinson's Disease.
Parkinson's disease
2017

Complex genetics of Tourette's Syndrome: Piecing the puzzle.
Movement disorders : official journal of the Movement Disorder Society
2017

Cognitive Impact of Deep Brain Stimulation on Parkinson's Disease Patients.
Parkinson's disease
2017

Botulinum Toxin Therapy for Parkinson's Disease.
Seminars in neurology
2017

ADS 5102 (Amantadine) Extended Release for Levodopa-Induced Dyskinesia-Reply.
JAMA neurology
2017

A Randomized Trial of Relamorelin for Constipation in Parkinson's Disease (Move-Pd): Trial Results and Lessons Learned
Parkinsonism & Related Disorders
2017

Variables associated with physical health-related quality of life in Parkinson's disease patients presenting for deep brain stimulation.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2016

State of the Art for Deep Brain Stimulation Therapy in Movement Disorders: A Clinical and Technological Perspective.
IEEE reviews in biomedical engineering
2016

Repetitive Transcranial Magnetic Stimulation (rTMS) Therapy in Parkinson Disease: A Meta-Analysis.
PM & R : the journal of injury, function, and rehabilitation
2016

Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies.
Frontiers in integrative neuroscience
2016

Occurrence of Dysphagia Following Botulinum Toxin Injection in Parkinsonism-related Cervical Dystonia: A Retrospective Study.
Tremor and other hyperkinetic movements (New York, N.Y.)
2016

Multifocal repetitive TMS for motor and mood symptoms of Parkinson disease: A randomized trial.
Neurology
2016

High rates of fatigue and sleep disturbances in dystonia.
The International journal of neuroscience
2016

Erratum to: Variables associated with physical health-related quality of life in Parkinson's disease patients presenting for deep brain stimulation.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2016

Deep Brain Stimulation in a Case of Mitochondrial Disease.
Movement disorders clinical practice
2016

Benign tremulous Parkinsonism: a unique entity or another facet of Parkinson's disease?
Translational neurodegeneration
2016

Association between antidepressants and falls in Parkinson's disease.
Journal of neurology
2016

Update on deep brain stimulation in Parkinson's disease.
Translational neurodegeneration
2015

Unexpected dual task benefits on cycling in Parkinson disease and healthy adults: a neuro-behavioral model.
PloS one
2015

Rate of aspiration pneumonia in hospitalized Parkinson's disease patients: a cross-sectional study.
BMC neurology
2015

Missing dosages and neuroleptic usage may prolong length of stay in hospitalized Parkinson's disease patients.
PloS one
2015

Global attentional neglect of segmented lines in Parkinson's disease.
Neurocase
2015

Functional Brain Activity Relates to 0-3 and 3-8 Hz Force Oscillations in Essential Tremor.
Cerebral cortex (New York, N.Y. : 1991)
2015

Abnormal tactile pressure perception in Parkinson's disease.
Journal of clinical and experimental neuropsychology
2015

Treatment and physiology in Parkinson's disease and dystonia: using transcranial magnetic stimulation to uncover the mechanisms of action.
Current neurology and neuroscience reports
2014

The "brittle response" to Parkinson's disease medications: characterization and response to deep brain stimulation.
PloS one
2014

Surgical treatment of Parkinson's disease: patients, targets, devices, and approaches.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2014

Defining the clinically meaningful difference in gait speed in persons with Parkinson disease.
Journal of neurologic physical therapy : JNPT
2014

Comparable Botulinum Toxin Outcomes between Primary and Secondary Blepharospasm: A Retrospective Analysis.
Tremor and other hyperkinetic movements (New York, N.Y.)
2014

An eight-year clinic experience with clozapine use in a Parkinson's disease clinic setting.
PloS one
2014

Unilateral thalamic deep brain stimulation in essential tremor demonstrates long-term ipsilateral effects.
Parkinsonism & related disorders
2013

Postural/Gait and cognitive function as predictors of driving performance in Parkinson's disease.
Journal of Parkinson's disease
2013

Long-term subthalamic nucleus stimulation improves sensorimotor integration and proprioception.
Journal of neurology, neurosurgery, and psychiatry
2013

Impact of discontinuing tremor suppressing medications following thalamic deep brain stimulation.
Parkinsonism & related disorders
2013

Driving performance and behaviors: a comparison of gender differences in Parkinson's disease.
Traffic injury prevention
2013

Worsening essential tremor following deep brain stimulation: disease progression versus tolerance.
Brain : a journal of neurology
2012

Quantitative normative gait data in a large cohort of ambulatory persons with Parkinson's disease.
PloS one
2012

Personalized medicine in deep brain stimulation through utilization of neural oscillations.
Neurology
2012

Micrographia and related deficits in Parkinson's disease: a cross-sectional study.
BMJ open
2012

Fatigue, Sleepiness and Sleep Issues in Patients With Dystonia

2012

Emerging opportunities for serotypes of botulinum neurotoxins.
Toxins
2012

A case of an arachnoid cyst masquerading as corticobasal degeneration.
The Clinical neuropsychologist
2012

Research Interests

Dr. Wagle Shukla is committed to research in movement disorders in many ways. She is the director for transcranial magnetic stimulation (TMS) Laboratory and the co-director for clinical trials in essential tremor, dystonia, Parkinson’s disease, Huntington’s disease and Tourette syndrome to develop better treatments for these conditions. Dr. Wagle Shukla has been appointed as the Director for the Neurophysiology core research lab at the Fixel Institute for Neurological Diseases. The mission of the core lab is to advance the electrophysiological understanding of tremors, dystonia, myoclonus, and psychogenic movement disorders. She is the clinical director for Tyler’s Hope Foundation for Dystonia and a member of Tremor Research Group.

Dr. Wagle Shukla is working on many projects to elucidate the mechanisms underlying dystonia, dystonia treatments and develop novel treatments for dystonia, particularly involving the use of noninvasive repetitive TMS in conjunction with oral pharmacological therapies, botulinum toxin injections, and DBS surgery. She is working on increasing the applications of rehabilitation therapies in the field of movement disorders. Similarly, Dr. Wagle Shukla is also working on many tremor disorders, including essential tremor, Parkinson’s disease, dystonic tremor, and orthostatic tremor. She has been awarded numerous grants for this research through the Dystonia Coalition, Dystonia Medical Research Foundation, CTSI at UF (National Institute of Health sponsored KL2 grant), Brain and Spinal Cord Injury Research Trust Fund, Blepharospasm Research Foundation, National Organization for Rare Disorders and the National Institute of Health (NINDS K23 Grant). She has made several international presentations on her research and has more than 70 publications in many prestigious peer-reviewed journals including, Brain, Neurology, Journal of Neurology and Neurosurgery and Movement Disorders.